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• W3203003485 abstract "ABSTRACT For individual neurons to function appropriately within a network that is undergoing synaptic reorganization and refinement due to developmental or experience-dependent changes in circuit activity, they must homeostatically adapt their intrinsic excitability to maintain a consistent output despite the changing levels of synaptic input. This homeostatic plasticity of excitability is particularly important for the development of sensory circuits, where subtle deficits in neuronal and circuit function cause developmental disorders including autism spectrum disorder and epilepsy. Despite the critical importance of this process for normal circuit development, the molecular mechanism by which this homeostatic control of intrinsic excitability is regulated is not fully understood. Here, we demonstrate that Xenopus optic tectal neurons express distinct fast, persistent and resurgent Na + currents. Here, we demonstrate that Xenopus optic tectal neurons express distinct fast, persistent and resurgent Na + currents. These are regulated with developmental changes in synaptic input, and homeostatically in response to changes in visual input. We show that expression of the voltage-gated Na + channel subtype Na v 1.6 is regulated with changes in intrinsic excitability, that blocking Na v 1.6 channels is sufficient to decrease intrinsic excitability. Furthermore, that upregulation of Na v 1.6 expression is necessary for experience-dependent increases in Na + currents and intrinsic excitability. Finally, by examining behaviors that rely on visual and multisensory integration, we extend these findings to show that tight regulation of Na + channel gene expression during a critical period of tectal circuit development is required for the normal functional development of the tectal circuitry." @default.
• W3203003485 created "2021-10-11" @default.
• W3203003485 creator A5002661645 @default.
• W3203003485 creator A5080997160 @default.
• W3203003485 date "2021-10-08" @default.
• W3203003485 modified "2023-09-27" @default.
• W3203003485 title "Regulation of Na_v1.6-mediated sodium currents underlie the homeostatic control of neuronal intrinsic excitability in the optic tectum of the developing<i>Xenopus laevis</i>tadpole" @default.
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• W3203003485 doi "https://doi.org/10.1101/2021.10.07.463558" @default.
• W3203003485 hasPublicationYear "2021" @default.
• W3203003485 type Work @default.
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