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• W3203003553 abstract "Latar Belakang. Infark miokard akut adalah salah satu penyebab utama morbiditas dan mortalitas di seluruh dunia. Mikropartikel adalah vesikel membran yang dilepaskan dari berbagai jenis sel, setelah aktivasi atau apoptosis, dan hadir pada individu yang sehat dan pada pasien dengan patologi yang berbeda. Sebagian besar mikropartikel dilepas oleh platelet, yang disebut mikropartikel platelet. Hiperglikemia mengacu pada kelebihan kadar glukosa darah dalam aliran darah dan terkait dengan peningkatan risiko kematian pada pasien dengan infark miokard akut. Namun, penelitian lebih lanjut diperlukan untuk menentukan korelasi hiperglikemia pada mikropartikel platelet pada pasien dengan infark miokard akut. Tujuan. Penelitian ini bertujuan untuk menentukan korelasi hiperglikemia pada mikropartikel platelet pada pasien dengan infark miokard akut. Metode. Penelitian ini merupakan penelitian observasional menggunakan desain cross sectional. Sampel diambil secara berurutan dari minimal 100 pasien dengan infark miokard akut yang dirawat di rumah sakit di ICCU RSUP Dr. Sardjito Yogyakarta dari Januari 2017 hingga November 2017. Diagnosis infark miokard akut dinilai dari anamnesis, 12 lead electrocardiography dan tes enzim jantung. Tes darah juga diambil untuk menentukan mikropartikel platelet dan kadar glukosa darah pada suatu waktu pada pasien dengan infark miokard akut. Hasil. Hasil analisis dalam penelitian ini telah menunjukkan bahwa tidak ada hubungan yang signifikan yang ditemukan antara hiperglikemia akut dan mikropartikel platelet pada pasien dengan infark miokard akut dengan p value 0.432. Kesimpulan. Tidak ada hubungan yang signifikan antara hiperglikemia akut dan mikropartikel platelet pada pasien dengan infark miokard akut.Background. Acute myocardial infarction is one of the leading causes of morbidity and mortality worldwide. Microparticles are membrane vesicles released from different cell types, after activation or apoptosis, and are present in healthy individuals and in patients with different pathologies. Most of the microparticles are being released by the platelets, platelet-derived microparticles. Hyperglycemia refers to an excess of blood glucose levels in the bloodstream and associated with an increased risk of death to patients with acute myocardial infarction. However, further studies are required to determine the correlation of hyperglycemia on platelet-derived microparticles in patients with acute myocardial infarction. Objective. This study was aimed to determine the correlation of hyperglycemia on platelet-derived microparticles in patients with acute myocardial infarction. Method. This study is an observational study using cross sectional study design. The samples are taken consecutively from minimum of 100 patients with acute myocardial infarction hospitalized in ICCU of RSUP Dr. Sardjito Yogyakarta from January 2017 until November 2017. The diagnosis of acute myocardial infarction is assessed from anamnesis, 12 lead electrocardiography and cardiac enzyme test. Blood test is also taken to determine platelet-derived microparticles and blood glucose level at a time in patients with acute myocardial infarction. Result. Result of the analysis in this study had been shown that there were no significant association found between acute hyperglycemia and platelet-derived microparticles in patients with acute myocardial infarction with p value of 0.432. Conclusion. There is no significant association between acute hyperglycemia and platelet-derived microparticles in patients with acute myocardial infarction." @default.
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• W3203003553 title "CORRELATION OF ACUTE HYPERGLYCEMIA ON PLATELET-DERIVED MICROPARTICLES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION" @default.
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