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- W3203013238 endingPage "1392" @default.
- W3203013238 startingPage "1373" @default.
- W3203013238 abstract "Identifying the source of one's pain has been a significant clinical challenge since the physical sensation of pain is felt to be subjective in nature and difficult to quantify. Also referred to as “pain drivers” or “pain generators,” diagnosing the source of pain is complicated by a lack of tools sufficiently sensitive and specific enough to pinpoint the location. Additionally, the experience of pain is not only modulated by the individual's threshold to painful stimuli but also a product of the individual's affective contributions, such as fear, anxiety, and previous experiences. Perhaps then to quantify and localize pain generators is to examine the degree of nociception and pronociceptive inflammation—that is, the extent of cellular, chemical, and molecular changes that occur in pain generating processes. Measuring changes in the local density of receptors, ion channels, mediators, and inflammatory/immune cells that are involved in the painful phenotype using targeted, highly sensitive, and specific molecular imaging approaches is, therefore, a promising approach toward objectively identifying peripheral pain generators. There are a growing number of ongoing clinical and preclinical imaging approaches, especially with inflammatory or pain-related positron emission tomography (PET) radiotracers, that can measure the degree of target concentration and thus serve as a readout for sites of pain generation. Further, when PET is combined with the spatial and contrast resolution afforded by MRI, nuclear medicine physicians and radiologists can potentially identify pain drivers with greater accuracy and confidence. Several of these molecular imaging approaches that are currently being developed to isolate the source of pain are described herein." @default.
- W3203013238 created "2021-10-11" @default.
- W3203013238 creator A5020169937 @default.
- W3203013238 creator A5032557601 @default.
- W3203013238 creator A5044405214 @default.
- W3203013238 creator A5057091244 @default.
- W3203013238 date "2021-01-01" @default.
- W3203013238 modified "2023-09-26" @default.
- W3203013238 title "Identifying Musculoskeletal Pain Generators Using Molecular Imaging" @default.
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