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- W3203015139 abstract "ABSTRACT RNAs in circulation carry sequence-specific regulatory information between cells in plant, animal, and host-pathogen systems. Such RNA can cross generational boundaries, as evidenced by double-stranded RNA (dsRNA) from somatic cells of the nematode C. elegans silencing genes of matching sequence in the germline and in progeny. Here we dissect the intergenerational path taken by dsRNA from parental circulation and discover that cytosolic entry in the parental germline and/or developing progeny through the dsRNA importer SID-1 varies based on developmental time and dsRNA substrates. Temporary loss of SID-1 causes changes in the expression of the s id-1 - d ependent g ene sdg-1 that can last for more than 100 generations. The SDG-1 protein is enriched in perinuclear Z granules required for heritable RNA silencing, but it is expressed from a retrotransposon targeted by such RNA silencing. This auto-inhibitory loop reveals how retrotransposons could persist over evolutionary time by hosting genes that regulate their own silencing." @default.
- W3203015139 created "2021-10-11" @default.
- W3203015139 creator A5022811044 @default.
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- W3203015139 creator A5076749694 @default.
- W3203015139 creator A5084789478 @default.
- W3203015139 date "2021-10-06" @default.
- W3203015139 modified "2023-09-24" @default.
- W3203015139 title "Intercellular transport of RNA can limit heritable epigenetic changes" @default.
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