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- W3203021081 abstract "Both human and mouse allergic contact dermatitis (ACD) frequently demonstrates a combined type 1 and type 2 immune response. However, the relative importance of type 2 immunity in this setting has been incompletely understood yet.To explore an effector function of type 2 immunity in ACD with mixed type 1/type 2 immune response.Gene expression characteristics of contact hypersensitivity (CHS) model was examined by quantitative polymerase chain reaction. Cytokine profile of T cells was analyzed by flow cytometry. The involvement of type 2 immunity was assessed by antibody-mediated cytokine neutralization and cell depletion. The role of specific subset of cutaneous dendritic cells was evaluated using diphtheria toxin-induced cell-depleting mouse strains.Oxazolone-induced CHS revealed a combination of type 1/type 2 gene expression. The severity of oxazolone-induced CHS was ameliorated by neutralization of IL-4 but not of IFN-γ, indicating that type 2 immunity plays a dominant effector function in this mixed type 1/type 2 model. Mechanistically, type 2 effector immunity was mounted by CD301b+Langeirn- dermal dendritic cells in part through thymic stromal lymphopoietin-interleukin 7 receptor alpha signaling-dependent manner.Our findings suggest the clinical rationale for targeting type 2 immunity as a relevant therapeutic strategy for the mixed immune phenotype of ACD." @default.
- W3203021081 created "2021-10-11" @default.
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- W3203021081 date "2021-11-01" @default.
- W3203021081 modified "2023-10-18" @default.
- W3203021081 title "Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response" @default.
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- W3203021081 doi "https://doi.org/10.1016/j.jdermsci.2021.10.001" @default.
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