Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203030812> ?p ?o ?g. }
- W3203030812 endingPage "11492" @default.
- W3203030812 startingPage "11484" @default.
- W3203030812 abstract "This paper reports the facile preparation of dual stimuli-responsive gel particles that simultaneously respond to weakly acidic and reducing stimuli and the application of these gel particles as a drug delivery carrier. The dual stimuli-responsive gel particles composed of a pH-responsive polymer network cross-linked with reduction stimuli-responsive disulfide cross-links, and biocompatible poly(ethylene glycol) cross-links were prepared by soap-free emulsion polymerization. The resulting gel particles were colloidally stable at physiological ionic strength and had a diameter of approximately 200 nm with a narrow size distribution. The resulting gel particles slightly swelled in an acidic environment. On the other hand, the gel particles drastically swelled under simultaneous weakly acidic and reducing conditions because of the ionization of tertiary amino groups in the gel network and a decrease in the cross-linking density resulting from cleavage of the disulfide cross-links. When cells were treated with the gel particles, they were taken up by cells via the endocytosis pathway and distributed in the cytosol after endosomal escape by the proton sponge effect. In addition, a hydrophobic drug, doxorubicin (Dox), was loaded into the gel particles through hydrophobic interactions. Dox was released from the gel particles under weakly acidic and reducing conditions, while the Dox release was inhibited at neutral pH. The weakly acidic pH- and reduction stimuli-responsive release of Dox from gel particles was attributed to the drastic swelling of these particles. The fascinating properties of the dual stimuli-responsive gel particles suggest that they can provide a useful platform for designing intracellular drug delivery carriers." @default.
- W3203030812 created "2021-10-11" @default.
- W3203030812 creator A5016088045 @default.
- W3203030812 creator A5036330211 @default.
- W3203030812 creator A5039946998 @default.
- W3203030812 creator A5052384897 @default.
- W3203030812 date "2021-09-25" @default.
- W3203030812 modified "2023-10-16" @default.
- W3203030812 title "Weakly Acidic pH and Reduction Dual Stimuli-Responsive Gel Particles" @default.
- W3203030812 cites W1569789584 @default.
- W3203030812 cites W1963674712 @default.
- W3203030812 cites W1971532176 @default.
- W3203030812 cites W1974273490 @default.
- W3203030812 cites W1975600277 @default.
- W3203030812 cites W1980397442 @default.
- W3203030812 cites W1988536671 @default.
- W3203030812 cites W1989704200 @default.
- W3203030812 cites W1996173073 @default.
- W3203030812 cites W2007086477 @default.
- W3203030812 cites W2008637159 @default.
- W3203030812 cites W2009409069 @default.
- W3203030812 cites W2014987477 @default.
- W3203030812 cites W2016380384 @default.
- W3203030812 cites W2021262702 @default.
- W3203030812 cites W2029041094 @default.
- W3203030812 cites W2030967651 @default.
- W3203030812 cites W2031230861 @default.
- W3203030812 cites W2031721610 @default.
- W3203030812 cites W2037027329 @default.
- W3203030812 cites W2044390916 @default.
- W3203030812 cites W2047715691 @default.
- W3203030812 cites W2053426009 @default.
- W3203030812 cites W2060409525 @default.
- W3203030812 cites W2062183112 @default.
- W3203030812 cites W2067855092 @default.
- W3203030812 cites W2068050569 @default.
- W3203030812 cites W2068809055 @default.
- W3203030812 cites W2072024298 @default.
- W3203030812 cites W2077442464 @default.
- W3203030812 cites W2086069830 @default.
- W3203030812 cites W2115468050 @default.
- W3203030812 cites W2124747687 @default.
- W3203030812 cites W2130166533 @default.
- W3203030812 cites W2130277532 @default.
- W3203030812 cites W2132789515 @default.
- W3203030812 cites W2132878122 @default.
- W3203030812 cites W2155151146 @default.
- W3203030812 cites W2163818897 @default.
- W3203030812 cites W2314335208 @default.
- W3203030812 cites W2319556652 @default.
- W3203030812 cites W2322787262 @default.
- W3203030812 cites W2346074453 @default.
- W3203030812 cites W2528801719 @default.
- W3203030812 cites W2758375617 @default.
- W3203030812 cites W2884260866 @default.
- W3203030812 cites W2892970891 @default.
- W3203030812 cites W2943167846 @default.
- W3203030812 cites W2945554430 @default.
- W3203030812 cites W2992606422 @default.
- W3203030812 cites W3084198171 @default.
- W3203030812 cites W3099409659 @default.
- W3203030812 cites W3136947721 @default.
- W3203030812 doi "https://doi.org/10.1021/acs.langmuir.1c01677" @default.
- W3203030812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34565150" @default.
- W3203030812 hasPublicationYear "2021" @default.
- W3203030812 type Work @default.
- W3203030812 sameAs 3203030812 @default.
- W3203030812 citedByCount "5" @default.
- W3203030812 countsByYear W32030308122022 @default.
- W3203030812 countsByYear W32030308122023 @default.
- W3203030812 crossrefType "journal-article" @default.
- W3203030812 hasAuthorship W3203030812A5016088045 @default.
- W3203030812 hasAuthorship W3203030812A5036330211 @default.
- W3203030812 hasAuthorship W3203030812A5039946998 @default.
- W3203030812 hasAuthorship W3203030812A5052384897 @default.
- W3203030812 hasConcept C10138342 @default.
- W3203030812 hasConcept C108586683 @default.
- W3203030812 hasConcept C11268172 @default.
- W3203030812 hasConcept C12554922 @default.
- W3203030812 hasConcept C127413603 @default.
- W3203030812 hasConcept C162324750 @default.
- W3203030812 hasConcept C178790620 @default.
- W3203030812 hasConcept C184651966 @default.
- W3203030812 hasConcept C185592680 @default.
- W3203030812 hasConcept C187428577 @default.
- W3203030812 hasConcept C188027245 @default.
- W3203030812 hasConcept C42360764 @default.
- W3203030812 hasConcept C43617362 @default.
- W3203030812 hasConcept C44228677 @default.
- W3203030812 hasConcept C521977710 @default.
- W3203030812 hasConcept C54400483 @default.
- W3203030812 hasConcept C86803240 @default.
- W3203030812 hasConceptScore W3203030812C10138342 @default.
- W3203030812 hasConceptScore W3203030812C108586683 @default.
- W3203030812 hasConceptScore W3203030812C11268172 @default.
- W3203030812 hasConceptScore W3203030812C12554922 @default.
- W3203030812 hasConceptScore W3203030812C127413603 @default.
- W3203030812 hasConceptScore W3203030812C162324750 @default.