FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203049957> ?p ?o ?g. }

• W3203049957 endingPage "1321" @default.
• W3203049957 startingPage "1321" @default.
• W3203049957 abstract "Currently, an increasing number of people are suffering from fatigue due to the state of their lifestyles, such as sedentary work in a relatively small space, irregular sleep patterns, or the lack of movement and exercise. The present study was designed to simulate the occurrence of fatigue in the above populations through a chronic restraint stress (CRS) model, and to reveal its dynamic processes and potential underlying molecular mechanisms. ICR mice were subjected to 8 h of restraint stress each day for 5, 10, or 15 days. It was found that the weight-loaded swimming performance, grip strength, and locomotor activity of the mice all decreased under CRS treatment, and that up to 15 days of CRS induced notable fatigue. Gastrocnemius muscle atrophy and some abnormal biochemical parameters related to fatigue under CRS were observed. Furthermore, transcriptome data showed that the changes in muscle cell metabolism and mitochondrial dysfunction were associated with the AMPK signaling pathway in CRS-treated mice. Western blotting analysis of the AMPK/PGC-1α signaling pathway revealed that CRS could decrease mitochondrial biogenesis and reduce the numbers of type I skeletal muscle fibers in the gastrocnemius of mice. CRS could also block the protective mitophagic flux to inhibit the abnormal clearance of damaged mitochondria. Our study suggests a critical link between muscle atrophy and CRS-induced fatigue in mice, suggesting that the pharmacological promotion of muscle and mitochondrial function can be used as a treatment for stress-induced fatigue." @default.
• W3203049957 created "2021-10-11" @default.
• W3203049957 creator A5008212048 @default.
• W3203049957 creator A5015407471 @default.
• W3203049957 creator A5029449056 @default.
• W3203049957 creator A5029679813 @default.
• W3203049957 creator A5040096854 @default.
• W3203049957 creator A5050574477 @default.
• W3203049957 creator A5087499787 @default.
• W3203049957 date "2021-09-26" @default.
• W3203049957 modified "2023-09-26" @default.
• W3203049957 title "Chronic Restraint Stress-Induced Muscle Atrophy Leads to Fatigue in Mice by Inhibiting the AMPK Signaling Pathway" @default.
• W3203049957 cites W1773487397 @default.
• W3203049957 cites W1970637701 @default.
• W3203049957 cites W1983160508 @default.
• W3203049957 cites W1995318529 @default.
• W3203049957 cites W2019901221 @default.
• W3203049957 cites W2025665129 @default.
• W3203049957 cites W2036787961 @default.
• W3203049957 cites W2044782567 @default.
• W3203049957 cites W2048006706 @default.
• W3203049957 cites W2053765200 @default.
• W3203049957 cites W2066042684 @default.
• W3203049957 cites W2070871404 @default.
• W3203049957 cites W2079580613 @default.
• W3203049957 cites W2082092138 @default.
• W3203049957 cites W2090356147 @default.
• W3203049957 cites W2091917093 @default.
• W3203049957 cites W2103659405 @default.
• W3203049957 cites W2105404724 @default.
• W3203049957 cites W2118188777 @default.
• W3203049957 cites W2130025116 @default.
• W3203049957 cites W2135424721 @default.
• W3203049957 cites W2264968725 @default.
• W3203049957 cites W2565630323 @default.
• W3203049957 cites W2598017237 @default.
• W3203049957 cites W2754186363 @default.
• W3203049957 cites W2802669193 @default.
• W3203049957 cites W2913807423 @default.
• W3203049957 cites W2915142269 @default.
• W3203049957 cites W2949550667 @default.
• W3203049957 cites W2968194763 @default.
• W3203049957 cites W2975286949 @default.
• W3203049957 cites W2978810474 @default.
• W3203049957 cites W2983084556 @default.
• W3203049957 cites W3004190979 @default.
• W3203049957 cites W3029401517 @default.
• W3203049957 cites W3036405253 @default.
• W3203049957 cites W3040225703 @default.
• W3203049957 cites W3040692543 @default.
• W3203049957 cites W3041258315 @default.
• W3203049957 cites W3047131348 @default.
• W3203049957 cites W3048787899 @default.
• W3203049957 cites W3082071627 @default.
• W3203049957 cites W3083833377 @default.
• W3203049957 cites W3091978595 @default.
• W3203049957 cites W3103775593 @default.
• W3203049957 cites W3115433314 @default.
• W3203049957 cites W4230857871 @default.
• W3203049957 cites W996206 @default.
• W3203049957 doi "https://doi.org/10.3390/biomedicines9101321" @default.
• W3203049957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533263" @default.
• W3203049957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680438" @default.
• W3203049957 hasPublicationYear "2021" @default.
• W3203049957 type Work @default.
• W3203049957 sameAs 3203049957 @default.
• W3203049957 citedByCount "3" @default.
• W3203049957 countsByYear W32030499572022 @default.
• W3203049957 countsByYear W32030499572023 @default.
• W3203049957 crossrefType "journal-article" @default.
• W3203049957 hasAuthorship W3203049957A5008212048 @default.
• W3203049957 hasAuthorship W3203049957A5015407471 @default.
• W3203049957 hasAuthorship W3203049957A5029449056 @default.
• W3203049957 hasAuthorship W3203049957A5029679813 @default.
• W3203049957 hasAuthorship W3203049957A5040096854 @default.
• W3203049957 hasAuthorship W3203049957A5050574477 @default.
• W3203049957 hasAuthorship W3203049957A5087499787 @default.
• W3203049957 hasBestOaLocation W32030499571 @default.
• W3203049957 hasConcept C11960822 @default.
• W3203049957 hasConcept C126322002 @default.
• W3203049957 hasConcept C134018914 @default.
• W3203049957 hasConcept C2775872116 @default.
• W3203049957 hasConcept C2776263037 @default.
• W3203049957 hasConcept C2777229759 @default.
• W3203049957 hasConcept C2779959927 @default.
• W3203049957 hasConcept C2780124434 @default.
• W3203049957 hasConcept C2781172350 @default.
• W3203049957 hasConcept C28859421 @default.
• W3203049957 hasConcept C71924100 @default.
• W3203049957 hasConcept C86803240 @default.
• W3203049957 hasConcept C95444343 @default.
• W3203049957 hasConcept C97029542 @default.
• W3203049957 hasConceptScore W3203049957C11960822 @default.
• W3203049957 hasConceptScore W3203049957C126322002 @default.
• W3203049957 hasConceptScore W3203049957C134018914 @default.
• W3203049957 hasConceptScore W3203049957C2775872116 @default.
• W3203049957 hasConceptScore W3203049957C2776263037 @default.
• W3203049957 hasConceptScore W3203049957C2777229759 @default.

• next