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- W3203081572 endingPage "e202101144" @default.
- W3203081572 startingPage "e202101144" @default.
- W3203081572 abstract "DNA damage is a double-edged sword for cancer cells. On the one hand, DNA damage-induced genomic instability contributes to cancer development; on the other hand, accumulating damage compromises proliferation and survival of cancer cells. Understanding the key regulators of DNA damage repair machinery would benefit the development of cancer therapies that induce DNA damage and apoptosis. In this study, we found that isoprenylcysteine carboxylmethyltransferase (ICMT), a posttranslational modification enzyme, plays an important role in DNA damage repair. We found that ICMT suppression consistently reduces the activity of MAPK signaling, which compromises the expression of key proteins in the DNA damage repair machinery. The ensuing accumulation of DNA damage leads to cell cycle arrest and apoptosis in multiple breast cancer cells. Interestingly, these observations are more pronounced in cells grown under anchorage-independent conditions or grown in vivo. Consistent with the negative impact on DNA repair, ICMT inhibition transforms the cancer cells into a BRCA-like state, hence sensitizing cancer cells to the treatment of PARP inhibitor and other DNA damage-inducing agents." @default.
- W3203081572 created "2021-10-11" @default.
- W3203081572 creator A5005686324 @default.
- W3203081572 creator A5009620598 @default.
- W3203081572 creator A5059386427 @default.
- W3203081572 date "2021-10-05" @default.
- W3203081572 modified "2023-10-02" @default.
- W3203081572 title "Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair" @default.
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