FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203106345> ?p ?o ?g. }

• W3203106345 endingPage "259" @default.
• W3203106345 startingPage "247" @default.
• W3203106345 abstract "Immunological monitoring plays a crucial role in organ recipients for allowing tailoring of immunosuppression. However, there is still a paucity of promising indicators for detecting immune status in recipients.We conducted a prospective study to characterize the immune status by detecting dynamically lymphocyte subsets and function (represented by the abilities to secrete IFN-γ) in the first 6 months posttransplant in renal recipients. Participants were classified into an immune stable group, infected group, and rejected group.In the stable group, our study suggested that the counts and function of CD4+ T, CD8+ T, and NK lymphocytes decreased to their nadir at week 2, and thereafter these indicators were gradually restored. The counts exceeded pre-operative levels, whereas function did not reach the pre-transplant levels by 6 months. We demonstrated that function of lymphocytes was considerably decreased in infected recipients compared with the stable group when infection occurred. By contrast, the function of lymphocytes was obviously increased at the point of rejection. Receiver operating characteristic (ROC) analysis in the combination of subsets and function of lymphocytes presented a superior clinical value with an area under the curve (AUC) of 0.903 in the diagnosis of infected receivers, and IFN-γ+CD8+ T cells% is the highest indicator with the auROC curve of 0.862. Another ROC analysis confirmed that IFN-γ+CD4 T cells% presented a preferable diagnostic value with an area of 0.887 for rejected recipients.In conclusion, the ability of lymphocyte subsets secreting IFN-γ may provide a promising assessment of immune status in recipients and allow timely modifying immunosuppression." @default.
• W3203106345 created "2021-10-11" @default.
• W3203106345 creator A5019858998 @default.
• W3203106345 creator A5030681379 @default.
• W3203106345 creator A5045477206 @default.
• W3203106345 creator A5065761001 @default.
• W3203106345 creator A5066533723 @default.
• W3203106345 creator A5068842308 @default.
• W3203106345 creator A5077299462 @default.
• W3203106345 date "2021-12-01" @default.
• W3203106345 modified "2023-09-26" @default.
• W3203106345 title "Lymphocyte function based on IFN-γ secretion assay may be a promising indicator for assessing different immune status in renal transplant recipients" @default.
• W3203106345 cites W1491970318 @default.
• W3203106345 cites W1708437872 @default.
• W3203106345 cites W1955294545 @default.
• W3203106345 cites W1981310820 @default.
• W3203106345 cites W1988926533 @default.
• W3203106345 cites W1989439033 @default.
• W3203106345 cites W2023577586 @default.
• W3203106345 cites W2037736267 @default.
• W3203106345 cites W2054334209 @default.
• W3203106345 cites W2064130337 @default.
• W3203106345 cites W2070525020 @default.
• W3203106345 cites W2073762826 @default.
• W3203106345 cites W2075150546 @default.
• W3203106345 cites W2099218143 @default.
• W3203106345 cites W2133372129 @default.
• W3203106345 cites W2162005954 @default.
• W3203106345 cites W2314567723 @default.
• W3203106345 cites W2467904883 @default.
• W3203106345 cites W2514689140 @default.
• W3203106345 cites W2550448067 @default.
• W3203106345 cites W2593532384 @default.
• W3203106345 cites W2755236455 @default.
• W3203106345 cites W2774126255 @default.
• W3203106345 cites W2792046181 @default.
• W3203106345 cites W2792724422 @default.
• W3203106345 cites W2793311913 @default.
• W3203106345 cites W2800143015 @default.
• W3203106345 cites W2899041044 @default.
• W3203106345 cites W2914973321 @default.
• W3203106345 cites W2914996830 @default.
• W3203106345 cites W2919675861 @default.
• W3203106345 cites W2996543668 @default.
• W3203106345 cites W3012493676 @default.
• W3203106345 cites W3025509810 @default.
• W3203106345 cites W3040327612 @default.
• W3203106345 cites W3044299959 @default.
• W3203106345 doi "https://doi.org/10.1016/j.cca.2021.10.003" @default.
• W3203106345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34626603" @default.
• W3203106345 hasPublicationYear "2021" @default.
• W3203106345 type Work @default.
• W3203106345 sameAs 3203106345 @default.
• W3203106345 citedByCount "2" @default.
• W3203106345 countsByYear W32031063452022 @default.
• W3203106345 countsByYear W32031063452023 @default.
• W3203106345 crossrefType "journal-article" @default.
• W3203106345 hasAuthorship W3203106345A5019858998 @default.
• W3203106345 hasAuthorship W3203106345A5030681379 @default.
• W3203106345 hasAuthorship W3203106345A5045477206 @default.
• W3203106345 hasAuthorship W3203106345A5065761001 @default.
• W3203106345 hasAuthorship W3203106345A5066533723 @default.
• W3203106345 hasAuthorship W3203106345A5068842308 @default.
• W3203106345 hasAuthorship W3203106345A5077299462 @default.
• W3203106345 hasConcept C114684123 @default.
• W3203106345 hasConcept C126322002 @default.
• W3203106345 hasConcept C167672396 @default.
• W3203106345 hasConcept C203014093 @default.
• W3203106345 hasConcept C2777761686 @default.
• W3203106345 hasConcept C2780252810 @default.
• W3203106345 hasConcept C3020391436 @default.
• W3203106345 hasConcept C58471807 @default.
• W3203106345 hasConcept C71924100 @default.
• W3203106345 hasConcept C86803240 @default.
• W3203106345 hasConcept C8891405 @default.
• W3203106345 hasConceptScore W3203106345C114684123 @default.
• W3203106345 hasConceptScore W3203106345C126322002 @default.
• W3203106345 hasConceptScore W3203106345C167672396 @default.
• W3203106345 hasConceptScore W3203106345C203014093 @default.
• W3203106345 hasConceptScore W3203106345C2777761686 @default.
• W3203106345 hasConceptScore W3203106345C2780252810 @default.
• W3203106345 hasConceptScore W3203106345C3020391436 @default.
• W3203106345 hasConceptScore W3203106345C58471807 @default.
• W3203106345 hasConceptScore W3203106345C71924100 @default.
• W3203106345 hasConceptScore W3203106345C86803240 @default.
• W3203106345 hasConceptScore W3203106345C8891405 @default.
• W3203106345 hasFunder F4320321001 @default.
• W3203106345 hasFunder F4320326688 @default.
• W3203106345 hasLocation W32031063451 @default.
• W3203106345 hasLocation W32031063452 @default.
• W3203106345 hasOpenAccess W3203106345 @default.
• W3203106345 hasPrimaryLocation W32031063451 @default.
• W3203106345 hasRelatedWork W2018979778 @default.
• W3203106345 hasRelatedWork W2349225001 @default.
• W3203106345 hasRelatedWork W2350566529 @default.
• W3203106345 hasRelatedWork W2357079228 @default.
• W3203106345 hasRelatedWork W2367868627 @default.
• W3203106345 hasRelatedWork W2367922297 @default.

• next