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• W3203110872 abstract "Mucus is a biological gel covering the surface of several tissues and insuring key biological functions, including as a protective barrier against dehydration, pathogens penetration, or gastric acids. Mucus biological functioning requires a finely tuned balance between solid-like and fluid-like mechanical response, insured by reversible bonds between mucins, the glycoproteins that form the gel. In living organisms, mucus is subject to various kinds of mechanical stresses, e.g. due to osmosis, bacterial penetration, coughing and gastric peristalsis. However, our knowledge of the effects of stress on mucus is still rudimentary and mostly limited to macroscopic rheological measurements, with no insight into the relevant microscopic mechanisms. Here, we run mechanical tests simultaneously to measurements of the microscopic dynamics of pig gastric mucus. Strikingly, we find that a modest shear stress, within the macroscopic rheological linear regime, dramatically enhances mucus reorganization at the microscopic level, as signalled by a transient acceleration of the microscopic dynamics, by up to two orders of magnitude. We rationalize these findings by proposing a simple yet general model for the dynamics of physical gels under strain and validate its assumptions through numerical simulations of spring networks. These results shed new light on the rearrangement dynamics of mucus at the microscopic scale, with potential implications in phenomena ranging from mucus clearance to bacterial and drug penetration." @default.
• W3203110872 created "2021-10-11" @default.
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• W3203110872 date "2021-10-03" @default.
• W3203110872 modified "2023-09-24" @default.
• W3203110872 title "Enhanced microscopic dynamics in mucus gels under a mechanical load in the linear viscoelastic regime" @default.
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• W3203110872 hasPublicationYear "2021" @default.
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