FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203111501> ?p ?o ?g. }

• W3203111501 abstract "The presence of variants in OBSCN was identified to be linked to hypertrophic cardiomyopathy (HCM), but whether OBSCN truncating variants were associated with HCM remained unknown.Whole-exome sequencing was performed in 986 patients with HCM and 761 non-HCM controls to search for OBSCN truncating variants, and the result was tested in a replication cohort consisting of 529 patients with HCM and 307 controls. The association of the OBSCN truncating variants with baseline characteristics and prognosis of patients with HCM were ascertained.There were 28 qualifying truncating variants in the OBSCN gene detected in 26 (2.6%) patients with HCM and 6 (0.8%) controls. The OBSCN truncating variants were more prevalent in patients with HCM than controls (odds ratio, 3.4, P=0.004). This association was confirmed in the replication cohort (odds ratio, 3.8, P=0.024). The combined effects of the two cohorts estimated the odds ratio to be 3.58 (P<0.001). Patients with or without OBSCN truncating variants shared similar demographic and echocardiographic variables at baseline. During 3.3±2.4 years (4795 patient-years) follow-up, the patients with OBSCN truncating variants were more likely to experience cardiovascular death (adjusted hazard ratio, 3.1 [95% CI, 1.40-6.70], P=0.005) and all-cause death (adjusted hazard ratio, 2.63 [95% CI, 1.21-5.71], P=0.015).Our data indicated that OBSCN truncating variants contributed to the disease-onset of HCM, and increased the risk of malignant events in patients with HCM." @default.
• W3203111501 created "2021-10-11" @default.
• W3203111501 creator A5007181654 @default.
• W3203111501 creator A5018159956 @default.
• W3203111501 creator A5042153705 @default.
• W3203111501 creator A5043112438 @default.
• W3203111501 creator A5045199115 @default.
• W3203111501 creator A5046454314 @default.
• W3203111501 creator A5056790120 @default.
• W3203111501 creator A5060008686 @default.
• W3203111501 creator A5062079293 @default.
• W3203111501 creator A5067328884 @default.
• W3203111501 creator A5067529225 @default.
• W3203111501 creator A5067550618 @default.
• W3203111501 date "2021-10-01" @default.
• W3203111501 modified "2023-09-24" @default.
• W3203111501 title "Truncating Variants in <i>OBSCN</i> Gene Associated With Disease-Onset and Outcomes of Hypertrophic Cardiomyopathy" @default.
• W3203111501 cites W1521859206 @default.
• W3203111501 cites W1971161141 @default.
• W3203111501 cites W1987736934 @default.
• W3203111501 cites W2021637659 @default.
• W3203111501 cites W2051978340 @default.
• W3203111501 cites W2055667304 @default.
• W3203111501 cites W2066541341 @default.
• W3203111501 cites W2090352597 @default.
• W3203111501 cites W2097618980 @default.
• W3203111501 cites W2099316238 @default.
• W3203111501 cites W2132659731 @default.
• W3203111501 cites W2140448398 @default.
• W3203111501 cites W2149422196 @default.
• W3203111501 cites W2155102198 @default.
• W3203111501 cites W2165354862 @default.
• W3203111501 cites W2416691116 @default.
• W3203111501 cites W2527407693 @default.
• W3203111501 cites W2551477390 @default.
• W3203111501 cites W2579055326 @default.
• W3203111501 cites W2622925544 @default.
• W3203111501 cites W2623076341 @default.
• W3203111501 cites W2800110583 @default.
• W3203111501 cites W2885240581 @default.
• W3203111501 cites W2911299823 @default.
• W3203111501 cites W3093305023 @default.
• W3203111501 cites W3106752039 @default.
• W3203111501 cites W3131875589 @default.
• W3203111501 cites W4210757612 @default.
• W3203111501 cites W74597864 @default.
• W3203111501 doi "https://doi.org/10.1161/circgen.121.003401" @default.
• W3203111501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34601892" @default.
• W3203111501 hasPublicationYear "2021" @default.
• W3203111501 type Work @default.
• W3203111501 sameAs 3203111501 @default.
• W3203111501 citedByCount "4" @default.
• W3203111501 countsByYear W32031115012022 @default.
• W3203111501 countsByYear W32031115012023 @default.
• W3203111501 crossrefType "journal-article" @default.
• W3203111501 hasAuthorship W3203111501A5007181654 @default.
• W3203111501 hasAuthorship W3203111501A5018159956 @default.
• W3203111501 hasAuthorship W3203111501A5042153705 @default.
• W3203111501 hasAuthorship W3203111501A5043112438 @default.
• W3203111501 hasAuthorship W3203111501A5045199115 @default.
• W3203111501 hasAuthorship W3203111501A5046454314 @default.
• W3203111501 hasAuthorship W3203111501A5056790120 @default.
• W3203111501 hasAuthorship W3203111501A5060008686 @default.
• W3203111501 hasAuthorship W3203111501A5062079293 @default.
• W3203111501 hasAuthorship W3203111501A5067328884 @default.
• W3203111501 hasAuthorship W3203111501A5067529225 @default.
• W3203111501 hasAuthorship W3203111501A5067550618 @default.
• W3203111501 hasBestOaLocation W32031115011 @default.
• W3203111501 hasConcept C126322002 @default.
• W3203111501 hasConcept C156957248 @default.
• W3203111501 hasConcept C164705383 @default.
• W3203111501 hasConcept C207103383 @default.
• W3203111501 hasConcept C2778198053 @default.
• W3203111501 hasConcept C2778797674 @default.
• W3203111501 hasConcept C2780185194 @default.
• W3203111501 hasConcept C44249647 @default.
• W3203111501 hasConcept C71924100 @default.
• W3203111501 hasConcept C72563966 @default.
• W3203111501 hasConceptScore W3203111501C126322002 @default.
• W3203111501 hasConceptScore W3203111501C156957248 @default.
• W3203111501 hasConceptScore W3203111501C164705383 @default.
• W3203111501 hasConceptScore W3203111501C207103383 @default.
• W3203111501 hasConceptScore W3203111501C2778198053 @default.
• W3203111501 hasConceptScore W3203111501C2778797674 @default.
• W3203111501 hasConceptScore W3203111501C2780185194 @default.
• W3203111501 hasConceptScore W3203111501C44249647 @default.
• W3203111501 hasConceptScore W3203111501C71924100 @default.
• W3203111501 hasConceptScore W3203111501C72563966 @default.
• W3203111501 hasIssue "5" @default.
• W3203111501 hasLocation W32031115011 @default.
• W3203111501 hasLocation W32031115012 @default.
• W3203111501 hasOpenAccess W3203111501 @default.
• W3203111501 hasPrimaryLocation W32031115011 @default.
• W3203111501 hasRelatedWork W2022392719 @default.
• W3203111501 hasRelatedWork W2064447907 @default.
• W3203111501 hasRelatedWork W2793590385 @default.
• W3203111501 hasRelatedWork W2804529914 @default.
• W3203111501 hasRelatedWork W2887472478 @default.
• W3203111501 hasRelatedWork W3017329712 @default.
• W3203111501 hasRelatedWork W3038392370 @default.

• next