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- W3203131058 abstract "Brainstem to spinal cord pathways modulate spinal neuronal activity. We implemented locus coeruleus (LC) targeting strategies by microinjecting CAV-PRS-ChR2 virus in the spinal cord (LC:SC module) or LC (LC:LC module). While activation of both modules inhibited evoked spinal neuronal firing via α1-adrenoceptor-mediated actions, LC:SC opto-activation abolished diffuse noxious inhibitory controls. The LC as a pain generator is likely mechanistically underpinned by maladaptive communication with discrete descending modulatory pathways." @default.
- W3203131058 created "2021-10-11" @default.
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- W3203131058 date "2021-09-26" @default.
- W3203131058 modified "2023-09-27" @default.
- W3203131058 title "Distinct brainstem to spinal cord noradrenergic pathways differentially regulate spinal neuronal activity" @default.
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- W3203131058 doi "https://doi.org/10.1101/2021.09.25.461801" @default.
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