Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203163670> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3203163670 abstract "Phenotypic heterogeneity within a bacterial population may confer new functionality and allow microorganisms to adapt to fluctuating environments. Previous work has suggested that Staphylococcus aureus could form small colony variants to avoid elimination by therapeutic antibiotics and host immunity systems. Here we show that a reversible non-pigment large colony morphology (Mu50∆lcpA-LC) was observed in S. aureus Mu50 after knocking out lcpA, coding for the LytR-CpsA-Psr family A protein. Mu50∆lcpA-LC increased resistance to β-lactam antibiotics, in addition, the enlarged cell size, enhanced spreading ability on solid medium, and reduced biofilm formation, suggesting better abilities for bacterial expansion. Moreover, the expression of spa encoding protein A was significantly increased in Mu50∆lcpA-LC. This study shows that besides the small colony variants, S. aureus could fight against antibiotics and host immunity through phenotype switching into a large colony variant." @default.
- W3203163670 created "2021-10-11" @default.
- W3203163670 creator A5031358233 @default.
- W3203163670 creator A5038564277 @default.
- W3203163670 creator A5044282595 @default.
- W3203163670 creator A5088004444 @default.
- W3203163670 date "2021-10-07" @default.
- W3203163670 modified "2023-09-25" @default.
- W3203163670 title "Phenotypic Switching of Staphylococcus aureus Mu50 Into a Large Colony Variant Enhances Heritable Resistance Against β-Lactam Antibiotics" @default.
- W3203163670 cites W1938292773 @default.
- W3203163670 cites W1974954111 @default.
- W3203163670 cites W1979973356 @default.
- W3203163670 cites W2002414185 @default.
- W3203163670 cites W2004880558 @default.
- W3203163670 cites W2036989796 @default.
- W3203163670 cites W2046739987 @default.
- W3203163670 cites W2056405753 @default.
- W3203163670 cites W2088960594 @default.
- W3203163670 cites W2098499925 @default.
- W3203163670 cites W2129062666 @default.
- W3203163670 cites W2143166347 @default.
- W3203163670 cites W2146614503 @default.
- W3203163670 cites W2152640773 @default.
- W3203163670 cites W2312720395 @default.
- W3203163670 cites W2407348712 @default.
- W3203163670 cites W2492391899 @default.
- W3203163670 cites W2587265764 @default.
- W3203163670 cites W2750504617 @default.
- W3203163670 cites W2754970075 @default.
- W3203163670 cites W2766734789 @default.
- W3203163670 cites W2787707083 @default.
- W3203163670 cites W2895414095 @default.
- W3203163670 cites W2912673401 @default.
- W3203163670 cites W2925443009 @default.
- W3203163670 cites W2971364670 @default.
- W3203163670 cites W2974261957 @default.
- W3203163670 cites W2981870649 @default.
- W3203163670 cites W3015386524 @default.
- W3203163670 doi "https://doi.org/10.3389/fmicb.2021.709841" @default.
- W3203163670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8530407" @default.
- W3203163670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34690952" @default.
- W3203163670 hasPublicationYear "2021" @default.
- W3203163670 type Work @default.
- W3203163670 sameAs 3203163670 @default.
- W3203163670 citedByCount "1" @default.
- W3203163670 countsByYear W32031636702022 @default.
- W3203163670 crossrefType "journal-article" @default.
- W3203163670 hasAuthorship W3203163670A5031358233 @default.
- W3203163670 hasAuthorship W3203163670A5038564277 @default.
- W3203163670 hasAuthorship W3203163670A5044282595 @default.
- W3203163670 hasAuthorship W3203163670A5088004444 @default.
- W3203163670 hasBestOaLocation W32031636701 @default.
- W3203163670 hasConcept C104317684 @default.
- W3203163670 hasConcept C127716648 @default.
- W3203163670 hasConcept C2779489039 @default.
- W3203163670 hasConcept C501593827 @default.
- W3203163670 hasConcept C523546767 @default.
- W3203163670 hasConcept C54355233 @default.
- W3203163670 hasConcept C58123911 @default.
- W3203163670 hasConcept C86803240 @default.
- W3203163670 hasConcept C89423630 @default.
- W3203163670 hasConcept C94665300 @default.
- W3203163670 hasConceptScore W3203163670C104317684 @default.
- W3203163670 hasConceptScore W3203163670C127716648 @default.
- W3203163670 hasConceptScore W3203163670C2779489039 @default.
- W3203163670 hasConceptScore W3203163670C501593827 @default.
- W3203163670 hasConceptScore W3203163670C523546767 @default.
- W3203163670 hasConceptScore W3203163670C54355233 @default.
- W3203163670 hasConceptScore W3203163670C58123911 @default.
- W3203163670 hasConceptScore W3203163670C86803240 @default.
- W3203163670 hasConceptScore W3203163670C89423630 @default.
- W3203163670 hasConceptScore W3203163670C94665300 @default.
- W3203163670 hasFunder F4320335777 @default.
- W3203163670 hasLocation W32031636701 @default.
- W3203163670 hasLocation W32031636702 @default.
- W3203163670 hasLocation W32031636703 @default.
- W3203163670 hasLocation W32031636704 @default.
- W3203163670 hasOpenAccess W3203163670 @default.
- W3203163670 hasPrimaryLocation W32031636701 @default.
- W3203163670 hasRelatedWork W1968602861 @default.
- W3203163670 hasRelatedWork W1977571916 @default.
- W3203163670 hasRelatedWork W2125076516 @default.
- W3203163670 hasRelatedWork W2326830576 @default.
- W3203163670 hasRelatedWork W2567289556 @default.
- W3203163670 hasRelatedWork W2954251670 @default.
- W3203163670 hasRelatedWork W3139452833 @default.
- W3203163670 hasRelatedWork W3190033734 @default.
- W3203163670 hasRelatedWork W4293862072 @default.
- W3203163670 hasRelatedWork W4378832553 @default.
- W3203163670 hasVolume "12" @default.
- W3203163670 isParatext "false" @default.
- W3203163670 isRetracted "false" @default.
- W3203163670 magId "3203163670" @default.
- W3203163670 workType "article" @default.