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- W3203182012 abstract "Abstract Introduction & Objective : Apoptosis, one of the most important mechanisms explaining stroke-induced functional deficit severity, might be reduced by physical rehabilitation. The purpose of this study is to assess effects of an 8-week endurance training both on apoptosis-related genes and proteins expression levels after a transient common carotid artery occlusion (tCCAO) in rats. Methods : Thirty Wistar male rats were randomly assigned into one of the 3 following groups: Control, tCCAO and tCCAO with endurance training (tCCAO+END). The tCCAO lasted 45 min. The endurance training was performed on treadmill over an 8-week period (5 days per week). BAX and BCL2 genes and proteins expression levels were used by qPCR, immunohistochemistry. Nissl staining was also carried out at the end of the training protocol. Results : The BAX expression increased following tCCAO but decreased when endurance training was performed (p<0.05). The BCL2 expression decreased following tCCAO and increased with training (p<0.05). In parallel, the cell death in the hippocampus was reduced when rats were trained. Conclusion : The endurance training can reduce the pro-apoptotic events after tCCAO suggesting a neuronal survival in the CA1 hippocampus. The link between apoptosis and functional recovery after training seems to be of clinical interest, and thus, should be more investigated." @default.
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- W3203182012 date "2021-07-13" @default.
- W3203182012 modified "2023-09-26" @default.
- W3203182012 title "The Endurance Training Effects on Apoptosis in the Rat Hippocampus Following Transient Common Carotid Artery Occlusion" @default.
- W3203182012 doi "https://doi.org/10.21203/rs.3.rs-694375/v1" @default.
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