Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203187002> ?p ?o ?g. }
- W3203187002 abstract "ABSTRACT Cardiac looping and trabeculation are key processes during cardiac chamber maturation. However, the underlying mechanisms remain incompletely understood. Here, we report the isolation, cloning and characterization of the proprotein convertase furina from the cardiovascular mutant loft in zebrafish. loft is an ethylnitrosourea-induced mutant and has evident defects in the cardiac outflow tract, heart looping and trabeculation, the craniofacial region and pharyngeal arch arteries. Positional cloning revealed that furina mRNA was barely detectable in loft mutants, and loft failed to complement the TALEN-induced furina mutant pku338, confirming that furina is responsible for the loft mutant phenotypes. Mechanistic studies demonstrated that Notch reporter Tg(tp1:mCherry) signals were largely eliminated in mutant hearts, and overexpression of the Notch intracellular domain partially rescued the mutant phenotypes, probably due to the lack of Furina-mediated cleavage processing of Notch1b proteins, the only Notch receptor expressed in the heart. Together, our data suggest a potential post-translational modification of Notch1b proteins via the proprotein convertase Furina in the heart, and unveil the function of the Furina-Notch1b axis in cardiac looping and trabeculation in zebrafish, and possibly in other organisms." @default.
- W3203187002 created "2021-10-11" @default.
- W3203187002 creator A5020085314 @default.
- W3203187002 creator A5031340346 @default.
- W3203187002 creator A5039360390 @default.
- W3203187002 creator A5041115227 @default.
- W3203187002 creator A5048038803 @default.
- W3203187002 creator A5054894456 @default.
- W3203187002 creator A5061738324 @default.
- W3203187002 creator A5076027011 @default.
- W3203187002 creator A5081180912 @default.
- W3203187002 creator A5088143400 @default.
- W3203187002 date "2021-11-01" @default.
- W3203187002 modified "2023-10-12" @default.
- W3203187002 title "Proprotein convertase furina is required for heart development in zebrafish" @default.
- W3203187002 cites W1617464831 @default.
- W3203187002 cites W1618025150 @default.
- W3203187002 cites W1949779925 @default.
- W3203187002 cites W1967102740 @default.
- W3203187002 cites W1973938885 @default.
- W3203187002 cites W1975911943 @default.
- W3203187002 cites W1976971221 @default.
- W3203187002 cites W1984393899 @default.
- W3203187002 cites W1993978935 @default.
- W3203187002 cites W1994509681 @default.
- W3203187002 cites W1996648013 @default.
- W3203187002 cites W2000779896 @default.
- W3203187002 cites W2002970726 @default.
- W3203187002 cites W2008205503 @default.
- W3203187002 cites W2017923546 @default.
- W3203187002 cites W2020044564 @default.
- W3203187002 cites W2020352822 @default.
- W3203187002 cites W2021062147 @default.
- W3203187002 cites W2023379590 @default.
- W3203187002 cites W2024657671 @default.
- W3203187002 cites W2025855348 @default.
- W3203187002 cites W2028429493 @default.
- W3203187002 cites W2056483214 @default.
- W3203187002 cites W2066302603 @default.
- W3203187002 cites W2072890764 @default.
- W3203187002 cites W2082195162 @default.
- W3203187002 cites W2082472219 @default.
- W3203187002 cites W2083348757 @default.
- W3203187002 cites W2088772927 @default.
- W3203187002 cites W2090164402 @default.
- W3203187002 cites W2098503611 @default.
- W3203187002 cites W2099997602 @default.
- W3203187002 cites W2101816987 @default.
- W3203187002 cites W2102308570 @default.
- W3203187002 cites W2110275759 @default.
- W3203187002 cites W2111818121 @default.
- W3203187002 cites W2120195060 @default.
- W3203187002 cites W2121985458 @default.
- W3203187002 cites W2126108762 @default.
- W3203187002 cites W2136670217 @default.
- W3203187002 cites W2141413750 @default.
- W3203187002 cites W2150627711 @default.
- W3203187002 cites W2153293603 @default.
- W3203187002 cites W2157132717 @default.
- W3203187002 cites W2168834654 @default.
- W3203187002 cites W2192409792 @default.
- W3203187002 cites W2193806089 @default.
- W3203187002 cites W2326707709 @default.
- W3203187002 cites W2335755161 @default.
- W3203187002 cites W2336594512 @default.
- W3203187002 cites W2466931552 @default.
- W3203187002 cites W2469597964 @default.
- W3203187002 cites W2557513796 @default.
- W3203187002 cites W2559956232 @default.
- W3203187002 cites W2750910159 @default.
- W3203187002 cites W2795185304 @default.
- W3203187002 cites W2802609582 @default.
- W3203187002 doi "https://doi.org/10.1242/jcs.258432" @default.
- W3203187002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34622921" @default.
- W3203187002 hasPublicationYear "2021" @default.
- W3203187002 type Work @default.
- W3203187002 sameAs 3203187002 @default.
- W3203187002 citedByCount "4" @default.
- W3203187002 countsByYear W32031870022023 @default.
- W3203187002 crossrefType "journal-article" @default.
- W3203187002 hasAuthorship W3203187002A5020085314 @default.
- W3203187002 hasAuthorship W3203187002A5031340346 @default.
- W3203187002 hasAuthorship W3203187002A5039360390 @default.
- W3203187002 hasAuthorship W3203187002A5041115227 @default.
- W3203187002 hasAuthorship W3203187002A5048038803 @default.
- W3203187002 hasAuthorship W3203187002A5054894456 @default.
- W3203187002 hasAuthorship W3203187002A5061738324 @default.
- W3203187002 hasAuthorship W3203187002A5076027011 @default.
- W3203187002 hasAuthorship W3203187002A5081180912 @default.
- W3203187002 hasAuthorship W3203187002A5088143400 @default.
- W3203187002 hasBestOaLocation W32031870021 @default.
- W3203187002 hasConcept C104317684 @default.
- W3203187002 hasConcept C134018914 @default.
- W3203187002 hasConcept C143065580 @default.
- W3203187002 hasConcept C145103041 @default.
- W3203187002 hasConcept C181199279 @default.
- W3203187002 hasConcept C2776878037 @default.
- W3203187002 hasConcept C2777265534 @default.
- W3203187002 hasConcept C2778163477 @default.
- W3203187002 hasConcept C2778824825 @default.