FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203187932> ?p ?o ?g. }

• W3203187932 abstract "We investigate the disynaptic effect of the hilar cells on pattern separation in a spiking neural network of the hippocampal dentate gyrus (DG). The principal granule cells (GCs) in the DG perform pattern separation, transforming similar input patterns into less-similar output patterns. In our DG network, the hilus consists of excitatory mossy cells (MCs) and inhibitory HIPP (hilar perforant path-associated) cells. Here, we consider the disynaptic effects of the MCs and the HIPP cells on the GCs, mediated by the inhibitory basket cells (BCs) in the granular layer; MC → BC → GC and HIPP → BC → GC. Disynaptic inhibition from the MCs tends to decrease the firing activity of the GCs. On the other hand, the HIPP cells disinhibit the intermediate BCs, which leads to increasing the activity of the GCs. By changing the synaptic strength K (BC,X) [from the presynaptic X (= MC or HIPP) to the postsynaptic BC] from the default value K (BC,X)* , we study the change in the pattern separation degree 𝒮 d . When decreasing K (BC,MC) or independently increasing K (BC,HIPP) from their default values, 𝒮 d is found to decrease (i.e., pattern separation is reduced). On the other hand, as K (BC,MC) is increased or independently K (BC,HIPP) is decreased from their default values, pattern separation becomes enhanced (i.e., 𝒮 d increases). In this way, the disynaptic effects of the MCs and the HIPP cells on the pattern separation are opposite ones. Thus, when simultaneously varying both K (BC,MC) and K (BC,HIPP) , as a result of balance between the two competing disynaptic effects of the MCs and the HIPP cells, 𝒮 d forms a bell-shaped curve with an optimal maximum at their default values. Moreover, we also investigate population and individual behaviors of the sparsely synchronized rhythm of the GCs, and find that the amplitude measure ℳ a (representing population synchronization degree) and the random-phase-locking degree ℒ d (denoting individual activity degree) are strongly correlated with the pattern separation degree 𝒮 d . Consequently, the larger the synchronization and the random phase-locking degrees of the sparsely synchronized rhythm is, the more the pattern separation becomes enhanced." @default.
• W3203187932 created "2021-10-11" @default.
• W3203187932 creator A5018513942 @default.
• W3203187932 creator A5029512205 @default.
• W3203187932 date "2021-09-24" @default.
• W3203187932 modified "2023-09-27" @default.
• W3203187932 title "Disynaptic Effect of Hilar Cells on Pattern Separation in A Spiking Neural Network of Hippocampal Dentate Gyrus" @default.
• W3203187932 cites W146465976 @default.
• W3203187932 cites W1495667643 @default.
• W3203187932 cites W1527064865 @default.
• W3203187932 cites W1536586062 @default.
• W3203187932 cites W1642619469 @default.
• W3203187932 cites W1843158289 @default.
• W3203187932 cites W1859586982 @default.
• W3203187932 cites W1868445472 @default.
• W3203187932 cites W1887565531 @default.
• W3203187932 cites W1940417817 @default.
• W3203187932 cites W1969677319 @default.
• W3203187932 cites W1970792572 @default.
• W3203187932 cites W1973134706 @default.
• W3203187932 cites W1975070097 @default.
• W3203187932 cites W1977694851 @default.
• W3203187932 cites W1980576528 @default.
• W3203187932 cites W1983442851 @default.
• W3203187932 cites W1986891212 @default.
• W3203187932 cites W1991579870 @default.
• W3203187932 cites W1993891869 @default.
• W3203187932 cites W2000336335 @default.
• W3203187932 cites W2003385862 @default.
• W3203187932 cites W2008513636 @default.
• W3203187932 cites W2012898751 @default.
• W3203187932 cites W2013427111 @default.
• W3203187932 cites W2023607741 @default.
• W3203187932 cites W2026233193 @default.
• W3203187932 cites W2026452842 @default.
• W3203187932 cites W2033062600 @default.
• W3203187932 cites W2036773579 @default.
• W3203187932 cites W2044101483 @default.
• W3203187932 cites W2046198005 @default.
• W3203187932 cites W2053389780 @default.
• W3203187932 cites W2059227777 @default.
• W3203187932 cites W2066020682 @default.
• W3203187932 cites W2073055671 @default.
• W3203187932 cites W2074304774 @default.
• W3203187932 cites W2088042096 @default.
• W3203187932 cites W2091451686 @default.
• W3203187932 cites W2097637304 @default.
• W3203187932 cites W2098552875 @default.
• W3203187932 cites W2098595367 @default.
• W3203187932 cites W2099751838 @default.
• W3203187932 cites W2101954189 @default.
• W3203187932 cites W2105089471 @default.
• W3203187932 cites W2107109377 @default.
• W3203187932 cites W2111405228 @default.
• W3203187932 cites W2119051448 @default.
• W3203187932 cites W2119381787 @default.
• W3203187932 cites W2120629471 @default.
• W3203187932 cites W2125818813 @default.
• W3203187932 cites W2126587466 @default.
• W3203187932 cites W2142925815 @default.
• W3203187932 cites W2143625506 @default.
• W3203187932 cites W2153631703 @default.
• W3203187932 cites W2154731415 @default.
• W3203187932 cites W2160498638 @default.
• W3203187932 cites W2551528265 @default.
• W3203187932 cites W2774235975 @default.
• W3203187932 cites W2783688988 @default.
• W3203187932 cites W2797375092 @default.
• W3203187932 cites W2899494972 @default.
• W3203187932 cites W2909553067 @default.
• W3203187932 cites W2952063041 @default.
• W3203187932 cites W2963372214 @default.
• W3203187932 cites W2993440152 @default.
• W3203187932 cites W3028605833 @default.
• W3203187932 cites W3107706150 @default.
• W3203187932 cites W3142507714 @default.
• W3203187932 cites W3161609592 @default.
• W3203187932 cites W3172446727 @default.
• W3203187932 cites W3203801295 @default.
• W3203187932 cites W4238614602 @default.
• W3203187932 cites W4244066340 @default.
• W3203187932 cites W889908523 @default.
• W3203187932 doi "https://doi.org/10.1101/2021.09.24.461624" @default.
• W3203187932 hasPublicationYear "2021" @default.
• W3203187932 type Work @default.
• W3203187932 sameAs 3203187932 @default.
• W3203187932 citedByCount "0" @default.
• W3203187932 crossrefType "posted-content" @default.
• W3203187932 hasAuthorship W3203187932A5018513942 @default.
• W3203187932 hasAuthorship W3203187932A5029512205 @default.
• W3203187932 hasBestOaLocation W32031879321 @default.
• W3203187932 hasConcept C112592302 @default.
• W3203187932 hasConcept C121332964 @default.
• W3203187932 hasConcept C148762608 @default.
• W3203187932 hasConcept C169760540 @default.
• W3203187932 hasConcept C17077164 @default.
• W3203187932 hasConcept C185592680 @default.
• W3203187932 hasConcept C2776168963 @default.
• W3203187932 hasConcept C2776464000 @default.
• W3203187932 hasConcept C86803240 @default.

• next