Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203193283> ?p ?o ?g. }
- W3203193283 endingPage "10403" @default.
- W3203193283 startingPage "10403" @default.
- W3203193283 abstract "Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Radiotherapy has long been an important treatment method of GBM. However, the intrinsic radioresistance of GBM cells is a key reason of poor therapeutic efficiency. Recently, many studies have shown that using the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) in radiotherapy may improve the prognosis of GBM patients, but the underlying molecular mechanisms remain unclear. In this study, Gene Expression Omnibus (GEO) datasets GSE153982 and GSE131956 were analyzed to evaluate radiation-induced changes of gene expression in GBM without or with SAHA treatment, respectively. Additionally, the survival-associated genes of GBM patients were screened using the Chinese Glioma Genome Atlas (CGGA) database. Taking the intersection of these three datasets, 11 survival-associated genes were discovered to be activated by irradiation and regulated by SAHA. The expressions of these genes were further verified in human GBM cell lines U251, T98G, and U251 homologous radioresistant cells (U251R) by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). It was found that MMP14 mRNA was considerably highly expressed in the radioresistant cell lines and was reduced by SAHA treatment. Transfection of MMP14 siRNA (siMMP14) suppressed cell survivals of these GBM cells after irradiation. Taken together, our results reveal for the first time that the MMP14 gene contributed to SAHA-induced radiosensitization of GBM." @default.
- W3203193283 created "2021-10-11" @default.
- W3203193283 creator A5013009635 @default.
- W3203193283 creator A5023371427 @default.
- W3203193283 creator A5025999663 @default.
- W3203193283 creator A5035833814 @default.
- W3203193283 creator A5043631775 @default.
- W3203193283 creator A5053262158 @default.
- W3203193283 creator A5056005532 @default.
- W3203193283 creator A5062594073 @default.
- W3203193283 creator A5076630615 @default.
- W3203193283 date "2021-09-27" @default.
- W3203193283 modified "2023-10-16" @default.
- W3203193283 title "MMP14 Contributes to HDAC Inhibition-Induced Radiosensitization of Glioblastoma" @default.
- W3203193283 cites W1582325190 @default.
- W3203193283 cites W1952281848 @default.
- W3203193283 cites W1965008416 @default.
- W3203193283 cites W1966416317 @default.
- W3203193283 cites W1967018540 @default.
- W3203193283 cites W1980638845 @default.
- W3203193283 cites W1981030303 @default.
- W3203193283 cites W1986586739 @default.
- W3203193283 cites W2031954417 @default.
- W3203193283 cites W2035618305 @default.
- W3203193283 cites W2047260073 @default.
- W3203193283 cites W2053406012 @default.
- W3203193283 cites W2062494807 @default.
- W3203193283 cites W2066264051 @default.
- W3203193283 cites W2088624336 @default.
- W3203193283 cites W2092462528 @default.
- W3203193283 cites W2093048712 @default.
- W3203193283 cites W2103665811 @default.
- W3203193283 cites W2107733280 @default.
- W3203193283 cites W2146512944 @default.
- W3203193283 cites W2149624674 @default.
- W3203193283 cites W2157247642 @default.
- W3203193283 cites W2158681922 @default.
- W3203193283 cites W2170830174 @default.
- W3203193283 cites W2171808845 @default.
- W3203193283 cites W2276640786 @default.
- W3203193283 cites W2469607447 @default.
- W3203193283 cites W2561629374 @default.
- W3203193283 cites W2749025438 @default.
- W3203193283 cites W2783692774 @default.
- W3203193283 cites W2805915902 @default.
- W3203193283 cites W2887874983 @default.
- W3203193283 cites W2903561390 @default.
- W3203193283 cites W2904215005 @default.
- W3203193283 cites W2951824462 @default.
- W3203193283 cites W2968818721 @default.
- W3203193283 cites W2970922664 @default.
- W3203193283 cites W2991552764 @default.
- W3203193283 cites W3016510951 @default.
- W3203193283 cites W3041604486 @default.
- W3203193283 cites W3043093285 @default.
- W3203193283 cites W3091419609 @default.
- W3203193283 cites W3097736767 @default.
- W3203193283 cites W3156932892 @default.
- W3203193283 cites W3172716480 @default.
- W3203193283 doi "https://doi.org/10.3390/ijms221910403" @default.
- W3203193283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8508883" @default.
- W3203193283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34638754" @default.
- W3203193283 hasPublicationYear "2021" @default.
- W3203193283 type Work @default.
- W3203193283 sameAs 3203193283 @default.
- W3203193283 citedByCount "1" @default.
- W3203193283 countsByYear W32031932832022 @default.
- W3203193283 crossrefType "journal-article" @default.
- W3203193283 hasAuthorship W3203193283A5013009635 @default.
- W3203193283 hasAuthorship W3203193283A5023371427 @default.
- W3203193283 hasAuthorship W3203193283A5025999663 @default.
- W3203193283 hasAuthorship W3203193283A5035833814 @default.
- W3203193283 hasAuthorship W3203193283A5043631775 @default.
- W3203193283 hasAuthorship W3203193283A5053262158 @default.
- W3203193283 hasAuthorship W3203193283A5056005532 @default.
- W3203193283 hasAuthorship W3203193283A5062594073 @default.
- W3203193283 hasAuthorship W3203193283A5076630615 @default.
- W3203193283 hasBestOaLocation W32031932831 @default.
- W3203193283 hasConcept C104317684 @default.
- W3203193283 hasConcept C2776202225 @default.
- W3203193283 hasConcept C2776262904 @default.
- W3203193283 hasConcept C2778227246 @default.
- W3203193283 hasConcept C2778305200 @default.
- W3203193283 hasConcept C502942594 @default.
- W3203193283 hasConcept C54009773 @default.
- W3203193283 hasConcept C54355233 @default.
- W3203193283 hasConcept C58962609 @default.
- W3203193283 hasConcept C64927066 @default.
- W3203193283 hasConcept C81885089 @default.
- W3203193283 hasConcept C86803240 @default.
- W3203193283 hasConceptScore W3203193283C104317684 @default.
- W3203193283 hasConceptScore W3203193283C2776202225 @default.
- W3203193283 hasConceptScore W3203193283C2776262904 @default.
- W3203193283 hasConceptScore W3203193283C2778227246 @default.
- W3203193283 hasConceptScore W3203193283C2778305200 @default.
- W3203193283 hasConceptScore W3203193283C502942594 @default.
- W3203193283 hasConceptScore W3203193283C54009773 @default.
- W3203193283 hasConceptScore W3203193283C54355233 @default.