Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203194823> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3203194823 endingPage "1120" @default.
- W3203194823 startingPage "1117" @default.
- W3203194823 abstract "Acacia species (Mimosaceae) is widely distributed in tropical and subtropical countries and has a variety of ethnomedicinal uses. There is inadequate laboratory investigation to identify bioactive compounds and therapeutic effect of Acacia nilotica var. ad stringens . This research has been conducted to extract, isolate and identify major compounds from heartwood of Acacia nilotica var. ad stringens and to test them against representative bacteria. Powdered air-dried heartwood of A. nilotica var. ad stringens has been extracted with methanol/water, 4:1 and the extract has been then purified using chromatographic techniques (column and paper chromatography). A pure flavonoid compound has been isolated and the structure has been elucidated based on extensive spectroscopic analysis procedures (IR, UV, 1 H NMR, and mass spectrometery). The isolated compound has then been evaluated for antimicrobial potential against Gram-negative ( Escherichia coli and Pseudomonas aeruginosa ) and Gram-positive bacteria ( Bacillus subtilis , Bacillus cereus , and Staphylococcus aureus ) using cup-plate agar diffusion method. The spectroscopic analysis of the isolated compound has led to its identification as 7,3ʹ,4ʹ-trihydroxyflavonol. The compound shows varying antimicrobial responses with high potency against Gram-negative human pathogens. The Gram-positive bacteria which are inhibited are Bacillus cereus, Corynebacterium sp. , Enterococcus faecalis, Staphylococcus aureus , and Streptococcus agalactiae. The Gram-negative bacteria are Acinetobacterbaumannii , Acinetobacter sp. , Escherichia coli, Pseudomonas aeruginosa and yeasts are Candida albicans and Cryptococcus neoformans. The present study has demonstrated that 7,3ʹ,4ʹ-trihydroxyflavonol is an effective antimicrobial compound. If applied in suitable pharmaceutical formulations it could be valuable for treating various bacterial infections or introduced as adjunct treatment along with standard agents." @default.
- W3203194823 created "2021-10-11" @default.
- W3203194823 creator A5004975317 @default.
- W3203194823 creator A5014000363 @default.
- W3203194823 creator A5037286286 @default.
- W3203194823 creator A5045521045 @default.
- W3203194823 creator A5045887934 @default.
- W3203194823 creator A5064476258 @default.
- W3203194823 creator A5084472225 @default.
- W3203194823 date "2021-07-10" @default.
- W3203194823 modified "2023-09-26" @default.
- W3203194823 title "Antimicrobial activity of 7,3ʹ,4ʹ-trihydroxyflavonol isolated from Acacia nilotica var. ad stringens" @default.
- W3203194823 hasPublicationYear "2021" @default.
- W3203194823 type Work @default.
- W3203194823 sameAs 3203194823 @default.
- W3203194823 citedByCount "0" @default.
- W3203194823 crossrefType "journal-article" @default.
- W3203194823 hasAuthorship W3203194823A5004975317 @default.
- W3203194823 hasAuthorship W3203194823A5014000363 @default.
- W3203194823 hasAuthorship W3203194823A5037286286 @default.
- W3203194823 hasAuthorship W3203194823A5045521045 @default.
- W3203194823 hasAuthorship W3203194823A5045887934 @default.
- W3203194823 hasAuthorship W3203194823A5064476258 @default.
- W3203194823 hasAuthorship W3203194823A5084472225 @default.
- W3203194823 hasConcept C104317684 @default.
- W3203194823 hasConcept C2777118263 @default.
- W3203194823 hasConcept C2779489039 @default.
- W3203194823 hasConcept C2779518903 @default.
- W3203194823 hasConcept C2779895986 @default.
- W3203194823 hasConcept C2780917455 @default.
- W3203194823 hasConcept C4937899 @default.
- W3203194823 hasConcept C523546767 @default.
- W3203194823 hasConcept C54355233 @default.
- W3203194823 hasConcept C547475151 @default.
- W3203194823 hasConcept C55493867 @default.
- W3203194823 hasConcept C86803240 @default.
- W3203194823 hasConcept C89423630 @default.
- W3203194823 hasConceptScore W3203194823C104317684 @default.
- W3203194823 hasConceptScore W3203194823C2777118263 @default.
- W3203194823 hasConceptScore W3203194823C2779489039 @default.
- W3203194823 hasConceptScore W3203194823C2779518903 @default.
- W3203194823 hasConceptScore W3203194823C2779895986 @default.
- W3203194823 hasConceptScore W3203194823C2780917455 @default.
- W3203194823 hasConceptScore W3203194823C4937899 @default.
- W3203194823 hasConceptScore W3203194823C523546767 @default.
- W3203194823 hasConceptScore W3203194823C54355233 @default.
- W3203194823 hasConceptScore W3203194823C547475151 @default.
- W3203194823 hasConceptScore W3203194823C55493867 @default.
- W3203194823 hasConceptScore W3203194823C86803240 @default.
- W3203194823 hasConceptScore W3203194823C89423630 @default.
- W3203194823 hasIssue "8" @default.
- W3203194823 hasLocation W32031948231 @default.
- W3203194823 hasOpenAccess W3203194823 @default.
- W3203194823 hasPrimaryLocation W32031948231 @default.
- W3203194823 hasRelatedWork W1516091235 @default.
- W3203194823 hasRelatedWork W2019363003 @default.
- W3203194823 hasRelatedWork W2103312265 @default.
- W3203194823 hasRelatedWork W2107813318 @default.
- W3203194823 hasRelatedWork W2121376534 @default.
- W3203194823 hasRelatedWork W2129921266 @default.
- W3203194823 hasRelatedWork W2140905910 @default.
- W3203194823 hasRelatedWork W2185401498 @default.
- W3203194823 hasRelatedWork W2371812895 @default.
- W3203194823 hasRelatedWork W2509498929 @default.
- W3203194823 hasRelatedWork W2549206511 @default.
- W3203194823 hasRelatedWork W2627079015 @default.
- W3203194823 hasRelatedWork W2977462391 @default.
- W3203194823 hasRelatedWork W2979521532 @default.
- W3203194823 hasRelatedWork W3006434496 @default.
- W3203194823 hasRelatedWork W3032199810 @default.
- W3203194823 hasRelatedWork W3096686496 @default.
- W3203194823 hasRelatedWork W3107924416 @default.
- W3203194823 hasRelatedWork W2188440512 @default.
- W3203194823 hasRelatedWork W2576297019 @default.
- W3203194823 hasVolume "60" @default.
- W3203194823 isParatext "false" @default.
- W3203194823 isRetracted "false" @default.
- W3203194823 magId "3203194823" @default.
- W3203194823 workType "article" @default.