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- W3203208539 abstract "This editorial refers to ‘A possible explanation for the contrasting results of REDUCE-IT vs. STRENGTH: cohort study mimicking trial designs’, by T. Doi et al., https://doi.org/10.1093/eurheartj/ehab555. Interest in the potential for long-chain omega-3 fatty acid intake to reduce atherosclerotic cardiovascular disease (ASCVD) risk dates back nearly 50 years to observations in Greenland Inuit, whose low rate of mortality from coronary heart disease (CHD) was found to be associated with high intakes of the fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA and DHA have several biological effects that might be expected to favourably impact ASCVD outcomes, including reducing circulating triglycerides; lowering blood pressures (systolic and diastolic); dampening platelet reactivity; moderating oxidative stress; and reducing biomarkers of chronic inflammation such as C-reactive protein (CRP), tumour necrosis factor-α and proinflammatory eicosanoids and leukotrienes.1–3 Randomized, controlled trials of omega-3 fatty acid interventions have produced mixed results. Many of..." @default.
- W3203208539 created "2021-10-11" @default.
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- W3203208539 date "2021-10-02" @default.
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- W3203208539 title "Investigating contrasting results in REDUCE-IT and STRENGTH: partial answers but questions remain" @default.
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- W3203208539 doi "https://doi.org/10.1093/eurheartj/ehab643" @default.
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