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• W3203217038 abstract "ABSTRACT Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here we show human translation initiation factor eIF3 interacts with select immune system related mRNAs including those encoding the T cell receptor (TCR) subunits TCRA and TCRB. Binding of eIF3 to the TCRA and TCRB mRNA 3’-untranslated regions (3’-UTRs) depends on CD28 coreceptor signaling and regulates a burst in TCR translation required for robust T cell activation. Use of the TCRA or TCRB 3’-UTRs to control expression of an anti-CD19 chimeric antigen receptor (CAR) improves the ability of CAR-T cells to kill tumor cells in vitro . These results identify a new mechanism of eIF3-mediated translation control that can aid T cell engineering for immunotherapy applications." @default.
• W3203217038 created "2021-10-11" @default.
• W3203217038 creator A5011844208 @default.
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• W3203217038 creator A5070915778 @default.
• W3203217038 creator A5074710825 @default.
• W3203217038 date "2021-10-04" @default.
• W3203217038 modified "2023-09-26" @default.
• W3203217038 title "Robust T cell activation requires an eIF3-driven burst in T cell receptor translation" @default.
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• W3203217038 doi "https://doi.org/10.1101/2021.10.04.463005" @default.

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