Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203240493> ?p ?o ?g. }
- W3203240493 abstract "Here, we describe a combinatorial approach to identify peptide shuttles that successfully traverse the multiple barriers to systemic drug delivery to the brain--1. the blood-brain barrier (BBB) and the 2. extracellular space (ECS) of the brain. Leveraging the excellent molecular diversity of M13 phage libraries, we identified peptides that actively transport across the BBB and diffuse through the extracellular matrix of the ECS in cell culture and in mice. These peptides demonstrate higher accumulation in the brain than gold standard peptides used in clinical trials. Importantly, these findings suggest that different sized therapeutics that were previous poorly permeable into the brain can accumulate at higher concentrations, thereby improving the therapeutic index and ultimate efficacy of drugs into the brain." @default.
- W3203240493 created "2021-10-11" @default.
- W3203240493 creator A5002119628 @default.
- W3203240493 creator A5016730386 @default.
- W3203240493 creator A5017893147 @default.
- W3203240493 creator A5044112759 @default.
- W3203240493 creator A5049001911 @default.
- W3203240493 creator A5061592234 @default.
- W3203240493 creator A5065711135 @default.
- W3203240493 creator A5075990017 @default.
- W3203240493 creator A5081610435 @default.
- W3203240493 date "2019-06-12" @default.
- W3203240493 modified "2023-09-23" @default.
- W3203240493 title "Brain-Penetrating Peptide Shuttles Across the Blood-Brain Barrier and Extracellular-like Space" @default.
- W3203240493 cites W133175338 @default.
- W3203240493 cites W1411310222 @default.
- W3203240493 cites W1557693542 @default.
- W3203240493 cites W1588363888 @default.
- W3203240493 cites W1779848053 @default.
- W3203240493 cites W1965556854 @default.
- W3203240493 cites W1971163936 @default.
- W3203240493 cites W1973627211 @default.
- W3203240493 cites W1975219368 @default.
- W3203240493 cites W1975304761 @default.
- W3203240493 cites W1976874629 @default.
- W3203240493 cites W1976970322 @default.
- W3203240493 cites W1978829982 @default.
- W3203240493 cites W1996719014 @default.
- W3203240493 cites W2002934128 @default.
- W3203240493 cites W2011139878 @default.
- W3203240493 cites W2017781491 @default.
- W3203240493 cites W2028667966 @default.
- W3203240493 cites W2032706441 @default.
- W3203240493 cites W2034307627 @default.
- W3203240493 cites W2040880670 @default.
- W3203240493 cites W2041229020 @default.
- W3203240493 cites W2044986100 @default.
- W3203240493 cites W2052465579 @default.
- W3203240493 cites W2056229778 @default.
- W3203240493 cites W2057569612 @default.
- W3203240493 cites W2060996573 @default.
- W3203240493 cites W2062940443 @default.
- W3203240493 cites W2066349153 @default.
- W3203240493 cites W2073077090 @default.
- W3203240493 cites W2073262413 @default.
- W3203240493 cites W2075306429 @default.
- W3203240493 cites W2078004577 @default.
- W3203240493 cites W2080445213 @default.
- W3203240493 cites W2085855890 @default.
- W3203240493 cites W2092876881 @default.
- W3203240493 cites W2096033084 @default.
- W3203240493 cites W2101099825 @default.
- W3203240493 cites W2104169059 @default.
- W3203240493 cites W2106495485 @default.
- W3203240493 cites W2108211417 @default.
- W3203240493 cites W2108485077 @default.
- W3203240493 cites W2111994795 @default.
- W3203240493 cites W2113588550 @default.
- W3203240493 cites W2115447066 @default.
- W3203240493 cites W2124551984 @default.
- W3203240493 cites W2135290713 @default.
- W3203240493 cites W2141518860 @default.
- W3203240493 cites W2142845165 @default.
- W3203240493 cites W2149706291 @default.
- W3203240493 cites W2153082486 @default.
- W3203240493 cites W2153578959 @default.
- W3203240493 cites W2159959024 @default.
- W3203240493 cites W2166811939 @default.
- W3203240493 cites W2172049535 @default.
- W3203240493 cites W2208467456 @default.
- W3203240493 cites W2253028130 @default.
- W3203240493 cites W2254055625 @default.
- W3203240493 cites W2255772379 @default.
- W3203240493 cites W2277219084 @default.
- W3203240493 cites W2296756579 @default.
- W3203240493 cites W2322545202 @default.
- W3203240493 cites W2338056426 @default.
- W3203240493 cites W2340200623 @default.
- W3203240493 cites W2421292429 @default.
- W3203240493 cites W2478243587 @default.
- W3203240493 cites W2510756767 @default.
- W3203240493 cites W2515466408 @default.
- W3203240493 cites W2531640839 @default.
- W3203240493 cites W2550482317 @default.
- W3203240493 cites W2554525706 @default.
- W3203240493 cites W2564088374 @default.
- W3203240493 cites W2587751387 @default.
- W3203240493 cites W2594239720 @default.
- W3203240493 cites W2772268163 @default.
- W3203240493 cites W2780217766 @default.
- W3203240493 cites W2805675343 @default.
- W3203240493 cites W2808897147 @default.
- W3203240493 cites W2896474470 @default.
- W3203240493 cites W818352397 @default.
- W3203240493 cites W1957701328 @default.
- W3203240493 doi "https://doi.org/10.26434/chemrxiv.8242871.v1" @default.
- W3203240493 hasPublicationYear "2019" @default.
- W3203240493 type Work @default.
- W3203240493 sameAs 3203240493 @default.
- W3203240493 citedByCount "0" @default.