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• W3203290843 endingPage "3340" @default.
• W3203290843 startingPage "3340" @default.
• W3203290843 abstract "Therapeutic selectivity is a critical issue in cancer therapy. As a result of its adjustable physicochemical characteristics, the Au/cellulose nanocomposite currently holds a lot of potential for solving this challenge. This work was designed to prepare a Au/cellulose nanocomposite with enhanced anticancer activity through the regulation of the mitogen-activated protein kinases (MAPK) signaling pathway. Nanocellulose, nanogold (AuNPs), and a Au/cellulose nanocomposite were biosynthesized from microgreen alga Chlorella vulgaris. Using UV-Vis absorption spectroscopy, transmission electron microscope (TEM), zeta potential analyzer, and Fourier transform infrared spectroscopy (FTIR), the synthesized nanoparticles were confirmed and characterized. In human alveolar basal epithelial cells (A549 cells), the selectivity and anticancer activity of the produced nanoparticles were evaluated. The cytotoxicity results revealed that the inhibitory concentration (IC50) of the Au/cellulose nanocomposite against A549 cancer lung cells was 4.67 ± 0.17 µg/µL compared to 182.75 ± 6.45 µg/µL in the case of HEL299 normal lung fibroblasts. It was found that treatment with nanocellulose and the Au/cellulose nanocomposite significantly increased (p < 0.05) the relative expression of tumor suppressor 53 (p53) in comparison to control cells. They also significantly (p < 0.05) decreased the relative expression of the Raf-1 gene. These findings indicate that nanocellulose and the Au/cellulose nanocomposite regulate cell cycles mostly via the motivation of p53 gene expression and reduction of Raf-1 gene expression." @default.
• W3203290843 created "2021-10-11" @default.
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• W3203290843 date "2021-09-29" @default.
• W3203290843 modified "2023-10-16" @default.
• W3203290843 title "Characterization and Anticancer Activity of Biosynthesized Au/Cellulose Nanocomposite from Chlorella vulgaris" @default.
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• W3203290843 doi "https://doi.org/10.3390/polym13193340" @default.
• W3203290843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8512388" @default.
• W3203290843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34641156" @default.
• W3203290843 hasPublicationYear "2021" @default.
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