Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203301114> ?p ?o ?g. }
- W3203301114 endingPage "1539" @default.
- W3203301114 startingPage "1539" @default.
- W3203301114 abstract "Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide in 2020. Colonoscopy and the fecal immunochemical test (FIT) are commonly used as CRC screening tests, but both types of tests possess different limitations. Recently, liquid biopsy-based DNA methylation test has become a powerful tool for cancer screening, and the detection of abnormal DNA methylation in stool specimens is considered as an effective approach for CRC screening. The aim of this study was to develop a novel approach in biomarker selection based on integrating primary biomarkers from genome-wide methylation profiles and secondary biomarkers from CRC comorbidity analytics. A total of 125 differential methylated probes (DMPs) were identified as primary biomarkers from 352 genome-wide methylation profiles. Among them, 51 biomarkers, including 48 hypermethylated DMPs and 3 hypomethylated DMPs, were considered as suitable DMP candidates for CRC screening tests. After comparing with commercial kits, three genes (ADHFE1, SDC2, and PPP2R5C) were selected as candidate epigenetic biomarkers for CRC screening tests. Methylation levels of these three biomarkers were significantly higher for patients with CRC than normal subjects. The sensitivity and specificity of integrating methylated ADHFE1, SDC2, and PPP2R5C for CRC detection achieved 84.6% and 92.3%, respectively. Through an integrated approach using genome-wide DNA methylation profiles and electronic medical records, we could design a biomarker panel that allows for early and accurate noninvasive detection of CRC using stool samples." @default.
- W3203301114 created "2021-10-11" @default.
- W3203301114 creator A5009572459 @default.
- W3203301114 creator A5031571854 @default.
- W3203301114 creator A5043791881 @default.
- W3203301114 creator A5051923121 @default.
- W3203301114 creator A5067778535 @default.
- W3203301114 creator A5071843228 @default.
- W3203301114 creator A5077115938 @default.
- W3203301114 creator A5078573194 @default.
- W3203301114 creator A5086428506 @default.
- W3203301114 creator A5087114705 @default.
- W3203301114 creator A5089929180 @default.
- W3203301114 creator A5090003103 @default.
- W3203301114 date "2021-09-28" @default.
- W3203301114 modified "2023-09-23" @default.
- W3203301114 title "Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test" @default.
- W3203301114 cites W1966968113 @default.
- W3203301114 cites W1982113893 @default.
- W3203301114 cites W1990118688 @default.
- W3203301114 cites W2013185838 @default.
- W3203301114 cites W2020150058 @default.
- W3203301114 cites W2030790825 @default.
- W3203301114 cites W2070544692 @default.
- W3203301114 cites W2071328133 @default.
- W3203301114 cites W2094775550 @default.
- W3203301114 cites W2099143036 @default.
- W3203301114 cites W2099828433 @default.
- W3203301114 cites W2109453679 @default.
- W3203301114 cites W2131201242 @default.
- W3203301114 cites W2136864841 @default.
- W3203301114 cites W2136895197 @default.
- W3203301114 cites W2144086069 @default.
- W3203301114 cites W2484161709 @default.
- W3203301114 cites W2584662705 @default.
- W3203301114 cites W2617093818 @default.
- W3203301114 cites W2624746969 @default.
- W3203301114 cites W2739592885 @default.
- W3203301114 cites W2766432045 @default.
- W3203301114 cites W2793868488 @default.
- W3203301114 cites W2809038982 @default.
- W3203301114 cites W2890089597 @default.
- W3203301114 cites W2910163800 @default.
- W3203301114 cites W2940062333 @default.
- W3203301114 cites W2943005888 @default.
- W3203301114 cites W2979072496 @default.
- W3203301114 cites W2984307858 @default.
- W3203301114 cites W2996131715 @default.
- W3203301114 cites W3017205270 @default.
- W3203301114 cites W3028817391 @default.
- W3203301114 cites W3092547406 @default.
- W3203301114 cites W3095421680 @default.
- W3203301114 cites W3128646645 @default.
- W3203301114 cites W3138018160 @default.
- W3203301114 cites W3155916313 @default.
- W3203301114 cites W3158871998 @default.
- W3203301114 cites W4211199921 @default.
- W3203301114 cites W4232177092 @default.
- W3203301114 doi "https://doi.org/10.3390/genes12101539" @default.
- W3203301114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8535797" @default.
- W3203301114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680934" @default.
- W3203301114 hasPublicationYear "2021" @default.
- W3203301114 type Work @default.
- W3203301114 sameAs 3203301114 @default.
- W3203301114 citedByCount "5" @default.
- W3203301114 countsByYear W32033011142022 @default.
- W3203301114 countsByYear W32033011142023 @default.
- W3203301114 crossrefType "journal-article" @default.
- W3203301114 hasAuthorship W3203301114A5009572459 @default.
- W3203301114 hasAuthorship W3203301114A5031571854 @default.
- W3203301114 hasAuthorship W3203301114A5043791881 @default.
- W3203301114 hasAuthorship W3203301114A5051923121 @default.
- W3203301114 hasAuthorship W3203301114A5067778535 @default.
- W3203301114 hasAuthorship W3203301114A5071843228 @default.
- W3203301114 hasAuthorship W3203301114A5077115938 @default.
- W3203301114 hasAuthorship W3203301114A5078573194 @default.
- W3203301114 hasAuthorship W3203301114A5086428506 @default.
- W3203301114 hasAuthorship W3203301114A5087114705 @default.
- W3203301114 hasAuthorship W3203301114A5089929180 @default.
- W3203301114 hasAuthorship W3203301114A5090003103 @default.
- W3203301114 hasBestOaLocation W32033011141 @default.
- W3203301114 hasConcept C104317684 @default.
- W3203301114 hasConcept C121608353 @default.
- W3203301114 hasConcept C124535831 @default.
- W3203301114 hasConcept C126322002 @default.
- W3203301114 hasConcept C143998085 @default.
- W3203301114 hasConcept C150194340 @default.
- W3203301114 hasConcept C190727270 @default.
- W3203301114 hasConcept C2781197716 @default.
- W3203301114 hasConcept C33288867 @default.
- W3203301114 hasConcept C41091548 @default.
- W3203301114 hasConcept C46111723 @default.
- W3203301114 hasConcept C526805850 @default.
- W3203301114 hasConcept C54355233 @default.
- W3203301114 hasConcept C60644358 @default.
- W3203301114 hasConcept C70721500 @default.
- W3203301114 hasConcept C71924100 @default.
- W3203301114 hasConcept C86803240 @default.