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- W3203312791 abstract "Tumorigenesis is generally driven by a combination of inherited genetic alterations and acquired somatic cell mutations. Glioma usually manifests sporadically, while certain tumors are now known to be associated with tumor predisposition syndromes. The spectrum of syndromes that have glioma manifestations includes neurofibromatosis types 1 and 2, tuberous sclerosis complex, Li-Fraumeni syndrome, Cowden syndrome, Turcot syndrome. A comprehensive understanding of the genetics and molecular pathogenesis of glioma is critical in improving clinical care and promoting the development of molecularly targeted therapeutics." @default.
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- W3203312791 date "2021-09-01" @default.
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- W3203312791 title "366P The genetic landscape of tumor predisposition syndromes in Chinese patients with glioma" @default.
- W3203312791 doi "https://doi.org/10.1016/j.annonc.2021.08.030" @default.
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