FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203313164> ?p ?o ?g. }

• W3203313164 endingPage "4881" @default.
• W3203313164 startingPage "4881" @default.
• W3203313164 abstract "Esophageal cancers confer a major health challenge and are highly aggressive malignancies with poor prognosis. Esophageal adenocarcinoma (EAC) is one of the two major histopathological subtypes of esophageal cancer. Despite advances in treatment modalities, the prognosis of patients with EAC remains poor, with a 5-year survival rate that rarely exceeds 30% in patients treated with curative intent. Chemoradiotherapy followed by resection is the treatment of choice for EAC patients, which are deemed to be curable. Current patient stratification and treatments are based on outcomes from clinical trials. Unfortunately, the molecular heterogeneity of EAC which determines the chemo- and radiosensitivity of these cancers are not taken into account. A more personalized approach in the treatment of EAC could improve patient outcomes. This review aims at summarizing literature on translational and clinical research in the field of EAC which could be of importance to develop personalized approaches. As suggested by the TCGA, expression data features molecular classifications by different platforms, including miRNA, genomic mutations and reverse-phase protein arrays. Here, we summarize literature on transcriptomic, data-driven approaches to identify distinct subtypes of EAC associated with molecular features. These novel classifications may determine the responsiveness to chemo(radio)therapy and help to identify novel molecular targets within cell signaling pathways. Moreover, we discuss the current clinical research efforts on tailored treatment regimens for patients with EAC taking into account the heterogeneous response to chemoradiotherapy. We summarize the evidence regarding active surveillance instead of immediate surgical resection after application of neoadjuvant chemo(radio)therapy in EAC. We consider that in future patients with complete response to chemo(radio)therapy, predicted by (transcriptomic) biomarkers, might benefit most from this approach. Finally, challenges to overcome for current findings to be implemented in clinical practice and move the field forward are being discussed." @default.
• W3203313164 created "2021-10-11" @default.
• W3203313164 creator A5002138998 @default.
• W3203313164 creator A5017152555 @default.
• W3203313164 creator A5039044781 @default.
• W3203313164 creator A5091623704 @default.
• W3203313164 date "2021-09-29" @default.
• W3203313164 modified "2023-09-27" @default.
• W3203313164 title "Towards Personalized Treatment Strategies for Esophageal Adenocarcinoma; A Review on the Molecular Characterization of Esophageal Adenocarcinoma and Current Research Efforts on Individualized Curative Treatment Regimens" @default.
• W3203313164 cites W1497915798 @default.
• W3203313164 cites W1575376507 @default.
• W3203313164 cites W1905322912 @default.
• W3203313164 cites W1922694287 @default.
• W3203313164 cites W1938378379 @default.
• W3203313164 cites W1967128680 @default.
• W3203313164 cites W1976922863 @default.
• W3203313164 cites W1977468182 @default.
• W3203313164 cites W1982186509 @default.
• W3203313164 cites W1993672158 @default.
• W3203313164 cites W1996753257 @default.
• W3203313164 cites W1999647740 @default.
• W3203313164 cites W2007278747 @default.
• W3203313164 cites W2015300224 @default.
• W3203313164 cites W2016348369 @default.
• W3203313164 cites W2045090755 @default.
• W3203313164 cites W2059562809 @default.
• W3203313164 cites W2060389567 @default.
• W3203313164 cites W2062002856 @default.
• W3203313164 cites W2076738949 @default.
• W3203313164 cites W2096192437 @default.
• W3203313164 cites W2113138482 @default.
• W3203313164 cites W2115072149 @default.
• W3203313164 cites W2121153992 @default.
• W3203313164 cites W2122166737 @default.
• W3203313164 cites W2123099168 @default.
• W3203313164 cites W2124427232 @default.
• W3203313164 cites W2126547130 @default.
• W3203313164 cites W2127114913 @default.
• W3203313164 cites W2127446202 @default.
• W3203313164 cites W2130177527 @default.
• W3203313164 cites W2132057594 @default.
• W3203313164 cites W2137696504 @default.
• W3203313164 cites W2140625837 @default.
• W3203313164 cites W2154444715 @default.
• W3203313164 cites W2156951180 @default.
• W3203313164 cites W2166135583 @default.
• W3203313164 cites W2189686546 @default.
• W3203313164 cites W2417335696 @default.
• W3203313164 cites W2515894228 @default.
• W3203313164 cites W2537321298 @default.
• W3203313164 cites W2560367415 @default.
• W3203313164 cites W2570401594 @default.
• W3203313164 cites W2726987475 @default.
• W3203313164 cites W2788485956 @default.
• W3203313164 cites W2805710293 @default.
• W3203313164 cites W2807082844 @default.
• W3203313164 cites W2870976737 @default.
• W3203313164 cites W2938216505 @default.
• W3203313164 cites W2938774982 @default.
• W3203313164 cites W2943266786 @default.
• W3203313164 cites W2946882113 @default.
• W3203313164 cites W2962724790 @default.
• W3203313164 cites W2993962988 @default.
• W3203313164 cites W3004063334 @default.
• W3203313164 cites W3004679173 @default.
• W3203313164 cites W3015736635 @default.
• W3203313164 cites W3015945406 @default.
• W3203313164 cites W3018483921 @default.
• W3203313164 cites W3096486123 @default.
• W3203313164 cites W3154482193 @default.
• W3203313164 cites W3160210194 @default.
• W3203313164 doi "https://doi.org/10.3390/cancers13194881" @default.
• W3203313164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8508226" @default.
• W3203313164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34638363" @default.
• W3203313164 hasPublicationYear "2021" @default.
• W3203313164 type Work @default.
• W3203313164 sameAs 3203313164 @default.
• W3203313164 citedByCount "4" @default.
• W3203313164 countsByYear W32033131642022 @default.
• W3203313164 countsByYear W32033131642023 @default.
• W3203313164 crossrefType "journal-article" @default.
• W3203313164 hasAuthorship W3203313164A5002138998 @default.
• W3203313164 hasAuthorship W3203313164A5017152555 @default.
• W3203313164 hasAuthorship W3203313164A5039044781 @default.
• W3203313164 hasAuthorship W3203313164A5091623704 @default.
• W3203313164 hasBestOaLocation W32033131641 @default.
• W3203313164 hasConcept C121608353 @default.
• W3203313164 hasConcept C126322002 @default.
• W3203313164 hasConcept C128544194 @default.
• W3203313164 hasConcept C142724271 @default.
• W3203313164 hasConcept C143998085 @default.
• W3203313164 hasConcept C2778292576 @default.
• W3203313164 hasConcept C2778424827 @default.
• W3203313164 hasConcept C2779742542 @default.
• W3203313164 hasConcept C2781182431 @default.
• W3203313164 hasConcept C2992824209 @default.
• W3203313164 hasConcept C32220436 @default.
• W3203313164 hasConcept C509974204 @default.

• next