FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203319793> ?p ?o ?g. }

• W3203319793 endingPage "4792" @default.
• W3203319793 startingPage "4782" @default.
• W3203319793 abstract "This study investigated the protective effect of total triterpenoids from Chaenomeles speciosa against Helicobacter pylori(Hp)-induced gastritis in mice and explored its possible mechanism. The chronic atrophic gastritis(CAG) model mice were randomly divided into four groups of model, total triterpenoids from C. speciosa(50 and 100 mg·kg~(-1)) and triple therapy, with C57 BL/6 J mice without Hp infection taken as the normal group. Mice in the treatment groups were given corresponding drugs once a day for 4 weeks. Then the following indexes were detected: the contents of reactive oxygen species(ROS), monocyte chemotactic protein 1(MCP-1), keratinocyte chemokines(KC), TNF-α, IL-1β, IL-6, IL-18, IL-4 and IL-10 in blood and gastric tissue, the activities and contents of LDH, MPO, SOD, GSH-Px, CAT and MDA in gastric tissue and the activities of β-glucuronidase, β-galactosidase, cathepsins B and D in blood, gastric tissue and lysosome. Besides, the mRNA expression levels of Toll-like receptor 4(TLR4), myeloid differentiation factor 88(MyD88), Bcl-2, Bcl-xl, Bax and Bad in gastric tissue were determined by quantitative real-time PCR. Western blot was employed to detect the protein expression levels of TLR4, MyD88, p-IKKβ, p-IκBα, NOD-like receptor 3(NLRP3), apoptosis-associated speck-like protein(ASC), pro-caspase-1, caspase-1, thioredoxin-interacting protein(TXNIP), pro-IL-1β, pro-IL-18, Bcl-2, Bcl-xl, Bax, Bad, cytochrome C, apoptotic protease-activating factor-1(Apaf-1), pro-caspase-9, pro-caspase-3, cleaved-caspase-9, cleaved-caspase-3, poly(ADP-ribose) polymerase 1(PARP-1), cleaved-PARP-1 and cytosol and nucleus NF-κB p65 in gastric tissue. The results indicated that the total triterpenoids from C. speciosa significantly suppressed Hp proliferation, alleviated the damage to gastric mucosa and improved lymphocyte infiltration and gland atrophy. They were also effective in reducing the activities of β-glucuronidase, β-galactosidase, cathepsins B and D in blood and gastric tissue, elevating the activities of β-glucuronidase and cathepsin D in lysosomal organelles, decreasing the contents of ROS, MCP-1, KC, TNF-α, IL-1β, IL-6, IL-18 in blood, MDA content and MPO and LDH activities in gastric tissue and increasing the contents of IL-4 and IL-10 in blood and activities of SOD, CAT and GSH-Px in gastric tissue. Other phenomena were also observed after the treatment with total triterpenoids from C. speciosa, including the down-regulation of the mRNA and protein expression levels of TLR4, MyD88, Bax and Bad, the protein expression levels of p-IKKβ, p-IκBα, NLRP3, ASC, pro-caspase-1, caspase-1, TXNIP, pro-IL-1β, pro-IL-18, cytochrome C, Apaf-1, cleaved-caspase-9, cleaved-caspase-3, cleaved-PARP-1 and nuclear NF-κB p65, reduction of p-IKKβ/IKKβ and p-IκBα/IκBα ratios and up-regulation of the mRNA and protein expression levels of Bcl-2 and Bcl-xl, up-regulation of pro-caspase-9, pro-caspace-3, cytosol NF-κB p65 protein expression levels and Bcl-2/Bax and Bcl-xl/Bad ratios in gastric tissue. These aforementioned results suggest that the total triterpenoids from C. speciosa have significant protective effects against CAG induced by Hp, and its mechanism may be related to enhancing the function of endogenous antioxidant system, suppressing the oxidative stress and inflammatory reaction induced by Hp, correcting lysosomal dysfunction and inflammatory activation of TLR4/NF-κB/NLRP3 inflammasome signaling pathway and thus inhibiting mitochondria-mediated apoptosis." @default.
• W3203319793 created "2021-10-11" @default.
• W3203319793 creator A5004116656 @default.
• W3203319793 creator A5006619229 @default.
• W3203319793 creator A5006639240 @default.
• W3203319793 creator A5042978732 @default.
• W3203319793 creator A5058010200 @default.
• W3203319793 creator A5062541798 @default.
• W3203319793 creator A5069190322 @default.
• W3203319793 creator A5081452468 @default.
• W3203319793 creator A5081536114 @default.
• W3203319793 date "2021-09-01" @default.
• W3203319793 modified "2023-10-16" @default.
• W3203319793 title "[Protective effect of total triterpenoids from Chaenomeles speciosa against Helicobacter pylori-induced gastritis in mice]." @default.
• W3203319793 doi "https://doi.org/10.19540/j.cnki.cjcmm.20210521.401" @default.
• W3203319793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34581089" @default.
• W3203319793 hasPublicationYear "2021" @default.
• W3203319793 type Work @default.
• W3203319793 sameAs 3203319793 @default.
• W3203319793 citedByCount "2" @default.
• W3203319793 countsByYear W32033197932022 @default.
• W3203319793 countsByYear W32033197932023 @default.
• W3203319793 crossrefType "journal-article" @default.
• W3203319793 hasAuthorship W3203319793A5004116656 @default.
• W3203319793 hasAuthorship W3203319793A5006619229 @default.
• W3203319793 hasAuthorship W3203319793A5006639240 @default.
• W3203319793 hasAuthorship W3203319793A5042978732 @default.
• W3203319793 hasAuthorship W3203319793A5058010200 @default.
• W3203319793 hasAuthorship W3203319793A5062541798 @default.
• W3203319793 hasAuthorship W3203319793A5069190322 @default.
• W3203319793 hasAuthorship W3203319793A5081452468 @default.
• W3203319793 hasAuthorship W3203319793A5081536114 @default.
• W3203319793 hasConcept C104317684 @default.
• W3203319793 hasConcept C126322002 @default.
• W3203319793 hasConcept C153911025 @default.
• W3203319793 hasConcept C185592680 @default.
• W3203319793 hasConcept C190283241 @default.
• W3203319793 hasConcept C203014093 @default.
• W3203319793 hasConcept C203565725 @default.
• W3203319793 hasConcept C2776409635 @default.
• W3203319793 hasConcept C2776415932 @default.
• W3203319793 hasConcept C2776914184 @default.
• W3203319793 hasConcept C31573885 @default.
• W3203319793 hasConcept C55493867 @default.
• W3203319793 hasConcept C66008609 @default.
• W3203319793 hasConcept C71924100 @default.
• W3203319793 hasConcept C86803240 @default.
• W3203319793 hasConcept C98274493 @default.
• W3203319793 hasConceptScore W3203319793C104317684 @default.
• W3203319793 hasConceptScore W3203319793C126322002 @default.
• W3203319793 hasConceptScore W3203319793C153911025 @default.
• W3203319793 hasConceptScore W3203319793C185592680 @default.
• W3203319793 hasConceptScore W3203319793C190283241 @default.
• W3203319793 hasConceptScore W3203319793C203014093 @default.
• W3203319793 hasConceptScore W3203319793C203565725 @default.
• W3203319793 hasConceptScore W3203319793C2776409635 @default.
• W3203319793 hasConceptScore W3203319793C2776415932 @default.
• W3203319793 hasConceptScore W3203319793C2776914184 @default.
• W3203319793 hasConceptScore W3203319793C31573885 @default.
• W3203319793 hasConceptScore W3203319793C55493867 @default.
• W3203319793 hasConceptScore W3203319793C66008609 @default.
• W3203319793 hasConceptScore W3203319793C71924100 @default.
• W3203319793 hasConceptScore W3203319793C86803240 @default.
• W3203319793 hasConceptScore W3203319793C98274493 @default.
• W3203319793 hasIssue "18" @default.
• W3203319793 hasLocation W32033197931 @default.
• W3203319793 hasOpenAccess W3203319793 @default.
• W3203319793 hasPrimaryLocation W32033197931 @default.
• W3203319793 hasRelatedWork W11924396 @default.
• W3203319793 hasRelatedWork W11983721 @default.
• W3203319793 hasRelatedWork W12537749 @default.
• W3203319793 hasRelatedWork W12708080 @default.
• W3203319793 hasRelatedWork W15014179 @default.
• W3203319793 hasRelatedWork W20360081 @default.
• W3203319793 hasRelatedWork W2223235 @default.
• W3203319793 hasRelatedWork W4087442 @default.
• W3203319793 hasRelatedWork W7976547 @default.
• W3203319793 hasRelatedWork W8906997 @default.
• W3203319793 hasVolume "46" @default.
• W3203319793 isParatext "false" @default.
• W3203319793 isRetracted "false" @default.
• W3203319793 magId "3203319793" @default.
• W3203319793 workType "article" @default.