Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203347345> ?p ?o ?g. }
- W3203347345 abstract "Triple-negative breast cancer (TNBC) has poor prognosis with limited treatment options, with little therapeutic progress made during the past several decades. DNA damage response (DDR) associated therapies, including radiation and inhibitors of DDR, demonstrate potential efficacy against TNBC, especially under the guidance of genomic subtype-directed treatment. The tumor immune microenvironment also contributes greatly to TNBC malignancy and response to conventional and targeted therapies. Immunotherapy represents a developing trend in targeted therapies directed against TNBC and strategies combining immunotherapy and modulators of the DDR pathways are being pursued. There is increasing understanding of the potential interplay between DDR pathways and immune-associated signaling. As such, the question of how we treat TNBC regarding novel immuno-molecular strategies is continually evolving. In this review, we explore the current and upcoming treatment options of TNBC in the context of DNA repair mechanisms and immune-based therapies, with a focus on implications of recent genomic analyses and clinical trial findings." @default.
- W3203347345 created "2021-10-11" @default.
- W3203347345 creator A5035724058 @default.
- W3203347345 creator A5054454197 @default.
- W3203347345 date "2021-09-24" @default.
- W3203347345 modified "2023-10-02" @default.
- W3203347345 title "Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer" @default.
- W3203347345 cites W1497172665 @default.
- W3203347345 cites W1559117436 @default.
- W3203347345 cites W1867175571 @default.
- W3203347345 cites W1973268287 @default.
- W3203347345 cites W1973388314 @default.
- W3203347345 cites W1984545852 @default.
- W3203347345 cites W1994826332 @default.
- W3203347345 cites W2009007206 @default.
- W3203347345 cites W2041993682 @default.
- W3203347345 cites W2054995801 @default.
- W3203347345 cites W2057187391 @default.
- W3203347345 cites W2061001563 @default.
- W3203347345 cites W2074730941 @default.
- W3203347345 cites W2086064725 @default.
- W3203347345 cites W2093350606 @default.
- W3203347345 cites W2094957481 @default.
- W3203347345 cites W2096283457 @default.
- W3203347345 cites W2096745115 @default.
- W3203347345 cites W2098683355 @default.
- W3203347345 cites W2098737737 @default.
- W3203347345 cites W2100039832 @default.
- W3203347345 cites W2116169737 @default.
- W3203347345 cites W2125885282 @default.
- W3203347345 cites W2126619407 @default.
- W3203347345 cites W2162856391 @default.
- W3203347345 cites W2270816365 @default.
- W3203347345 cites W2292067704 @default.
- W3203347345 cites W2308934048 @default.
- W3203347345 cites W2309983655 @default.
- W3203347345 cites W2343471288 @default.
- W3203347345 cites W2345415641 @default.
- W3203347345 cites W2402636472 @default.
- W3203347345 cites W2493219106 @default.
- W3203347345 cites W2513122557 @default.
- W3203347345 cites W2523826139 @default.
- W3203347345 cites W2527992063 @default.
- W3203347345 cites W2531029084 @default.
- W3203347345 cites W2558219863 @default.
- W3203347345 cites W2560827811 @default.
- W3203347345 cites W2565692949 @default.
- W3203347345 cites W2569252288 @default.
- W3203347345 cites W2573624273 @default.
- W3203347345 cites W2587333476 @default.
- W3203347345 cites W2587610309 @default.
- W3203347345 cites W2593633772 @default.
- W3203347345 cites W2597062310 @default.
- W3203347345 cites W2599047065 @default.
- W3203347345 cites W2604739492 @default.
- W3203347345 cites W2610368132 @default.
- W3203347345 cites W2613186675 @default.
- W3203347345 cites W2619520579 @default.
- W3203347345 cites W2621271973 @default.
- W3203347345 cites W2622573148 @default.
- W3203347345 cites W2625452721 @default.
- W3203347345 cites W2725398806 @default.
- W3203347345 cites W2737082469 @default.
- W3203347345 cites W2742116257 @default.
- W3203347345 cites W2751474182 @default.
- W3203347345 cites W2754600318 @default.
- W3203347345 cites W2754821104 @default.
- W3203347345 cites W2755866011 @default.
- W3203347345 cites W2764251734 @default.
- W3203347345 cites W2766673799 @default.
- W3203347345 cites W2767551096 @default.
- W3203347345 cites W2768434280 @default.
- W3203347345 cites W2779098860 @default.
- W3203347345 cites W2779221466 @default.
- W3203347345 cites W2782013082 @default.
- W3203347345 cites W2791483720 @default.
- W3203347345 cites W2802480234 @default.
- W3203347345 cites W2810414233 @default.
- W3203347345 cites W2886477543 @default.
- W3203347345 cites W2889136929 @default.
- W3203347345 cites W2890296921 @default.
- W3203347345 cites W2895846919 @default.
- W3203347345 cites W2897422388 @default.
- W3203347345 cites W2897523860 @default.
- W3203347345 cites W2902324525 @default.
- W3203347345 cites W2902655481 @default.
- W3203347345 cites W2909679049 @default.
- W3203347345 cites W2909799373 @default.
- W3203347345 cites W2909998834 @default.
- W3203347345 cites W2911100007 @default.
- W3203347345 cites W2911653212 @default.
- W3203347345 cites W2911718257 @default.
- W3203347345 cites W2912685686 @default.
- W3203347345 cites W2915645504 @default.
- W3203347345 cites W2918546246 @default.
- W3203347345 cites W2921768356 @default.
- W3203347345 cites W2924762495 @default.
- W3203347345 cites W2940452045 @default.
- W3203347345 cites W2942052760 @default.
- W3203347345 cites W2942628631 @default.