FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203381719> ?p ?o ?g. }

• W3203381719 endingPage "150561" @default.
• W3203381719 startingPage "150561" @default.
• W3203381719 abstract "Hydroxylated polybrominated diphenyl ethers (OH-BDEs) are major transformation products of PBDEs that readily bioaccumulate in the marine food web. Although 6-OH-BDE-47 is frequently and abundantly detected in cetaceans, its potential toxic effects are largely unknown. We explored the toxicological pathways and mechanisms of OH-BDEs by exposing pygmy killer whale skin fibroblast cell lines (PKW-LWHT) to 6-OH-BDE-47 at concentrations ranging from 0.02, 0.2, 2 to 4 μM. The result showed that 6-OH-BDE-47 inhibited cell proliferation in a concentration- and time-dependent manner. The cell cycle data revealed that the cell cycle was arrest at the G0/G1 phase by 6-OH-BDE-47. Using qPCR and Western blot assay, we found that 6-OH-BDE-47 up-regulated the transcription and expression level of p21 and RB1 and down-regulated the expression level of Proliferating Cell Nuclear Antigen (PCNA), CDK2, CDK4, cyclin D1, cyclin E2, E2F1, and E2F3 and the cellular phosphorylated RB1. The results showed that 6-OH-BDE-47 was able to arrest the cell cycle of PKW-LWHT cells at G1 phase by changing the expression level of related regulatory genes in G1 stage, and finally inhibit cell proliferation." @default.
• W3203381719 created "2021-10-11" @default.
• W3203381719 creator A5012613310 @default.
• W3203381719 creator A5047077366 @default.
• W3203381719 creator A5055065063 @default.
• W3203381719 creator A5073197534 @default.
• W3203381719 creator A5084685500 @default.
• W3203381719 creator A5091873586 @default.
• W3203381719 date "2022-02-01" @default.
• W3203381719 modified "2023-09-27" @default.
• W3203381719 title "6-OH-BDE-47 inhibited proliferation of skin fibroblasts from pygmy killer whale by inducing cell cycle arrest" @default.
• W3203381719 cites W1965498235 @default.
• W3203381719 cites W1967698159 @default.
• W3203381719 cites W1970897214 @default.
• W3203381719 cites W1980157584 @default.
• W3203381719 cites W1981524094 @default.
• W3203381719 cites W2010589168 @default.
• W3203381719 cites W2010926313 @default.
• W3203381719 cites W2013287222 @default.
• W3203381719 cites W2034277114 @default.
• W3203381719 cites W2034943673 @default.
• W3203381719 cites W2035519348 @default.
• W3203381719 cites W2038677177 @default.
• W3203381719 cites W2040753721 @default.
• W3203381719 cites W2042505301 @default.
• W3203381719 cites W2046323514 @default.
• W3203381719 cites W2053717292 @default.
• W3203381719 cites W2058429583 @default.
• W3203381719 cites W2069823876 @default.
• W3203381719 cites W2074298475 @default.
• W3203381719 cites W2083203908 @default.
• W3203381719 cites W2089353165 @default.
• W3203381719 cites W2092136005 @default.
• W3203381719 cites W2095493715 @default.
• W3203381719 cites W2103562965 @default.
• W3203381719 cites W2105799068 @default.
• W3203381719 cites W2108244474 @default.
• W3203381719 cites W2109115818 @default.
• W3203381719 cites W2130104270 @default.
• W3203381719 cites W2138020919 @default.
• W3203381719 cites W2143741133 @default.
• W3203381719 cites W2154207649 @default.
• W3203381719 cites W2302285932 @default.
• W3203381719 cites W2343423203 @default.
• W3203381719 cites W2512215639 @default.
• W3203381719 cites W2519786994 @default.
• W3203381719 cites W2548620727 @default.
• W3203381719 cites W2561416304 @default.
• W3203381719 cites W2603886489 @default.
• W3203381719 cites W2605188473 @default.
• W3203381719 cites W2768221484 @default.
• W3203381719 cites W2792507105 @default.
• W3203381719 cites W2792964809 @default.
• W3203381719 cites W2794078229 @default.
• W3203381719 cites W2794502472 @default.
• W3203381719 cites W2794767067 @default.
• W3203381719 cites W2808814831 @default.
• W3203381719 cites W284364657 @default.
• W3203381719 cites W2914187784 @default.
• W3203381719 cites W2951527960 @default.
• W3203381719 cites W2991603522 @default.
• W3203381719 cites W2995235349 @default.
• W3203381719 cites W2997764977 @default.
• W3203381719 cites W3016080919 @default.
• W3203381719 cites W3093221816 @default.
• W3203381719 cites W3108903653 @default.
• W3203381719 cites W3119875736 @default.
• W3203381719 cites W3134618697 @default.
• W3203381719 cites W3156201121 @default.
• W3203381719 cites W2415929253 @default.
• W3203381719 doi "https://doi.org/10.1016/j.scitotenv.2021.150561" @default.
• W3203381719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34624692" @default.
• W3203381719 hasPublicationYear "2022" @default.
• W3203381719 type Work @default.
• W3203381719 sameAs 3203381719 @default.
• W3203381719 citedByCount "1" @default.
• W3203381719 countsByYear W32033817192022 @default.
• W3203381719 crossrefType "journal-article" @default.
• W3203381719 hasAuthorship W3203381719A5012613310 @default.
• W3203381719 hasAuthorship W3203381719A5047077366 @default.
• W3203381719 hasAuthorship W3203381719A5055065063 @default.
• W3203381719 hasAuthorship W3203381719A5073197534 @default.
• W3203381719 hasAuthorship W3203381719A5084685500 @default.
• W3203381719 hasAuthorship W3203381719A5091873586 @default.
• W3203381719 hasConcept C105696609 @default.
• W3203381719 hasConcept C11882975 @default.
• W3203381719 hasConcept C120504264 @default.
• W3203381719 hasConcept C1491633281 @default.
• W3203381719 hasConcept C153911025 @default.
• W3203381719 hasConcept C16438837 @default.
• W3203381719 hasConcept C178790620 @default.
• W3203381719 hasConcept C185592680 @default.
• W3203381719 hasConcept C199835354 @default.
• W3203381719 hasConcept C25311885 @default.
• W3203381719 hasConcept C2778437423 @default.
• W3203381719 hasConcept C2780990795 @default.
• W3203381719 hasConcept C29537977 @default.
• W3203381719 hasConcept C34688535 @default.

• next