Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203382021> ?p ?o ?g. }
- W3203382021 abstract "Introduction. The emergence of multidrug-resistant Salmonella Typhimurium strains has increased the need for safe, alternative therapies from natural sources with antibacterial properties.Hypothesis/Gap Statement. There are no published data regarding the use of chitosan propolis nanocomposite (CPNP) either alone or in combination with antibiotics as antimicrobials against S. Typhimurium, especially in Egypt.Aim. This study evaluated the antibacterial activities of five antimicrobials [apramycin, propolis, chitosan nanoparticles (CNPs), chitosan propolis nanocomposite (CPNP) and CPNP +apramycin] against ten virulent and multidrug-resistant (MDR) S. Typhimurium field strains recovered from diarrheic rabbits through in vitro and in vivo study.Methodology. The expression levels of three virulence genes of S. Typhimurium strains were determined by quantitative reverse-transcription PCR (RT-qPCR) after exposure to sub-inhibitory concentrations of apramycin, propolis, CNPs, CPNP alone, and CPNP +apramycin. Additionally, 90 New Zealand rabbits were divided into control and experimentally S. Typhimurium-infected groups. The infected rabbits were orally administered saline solution (infected-untreated); 10 mg apramycin/kg (infected-apramycin-treated); 50 mg propolis/kg (infected-propolis-treated); 15 mg CPNP/kg (infected-CPNP-treated) and 15 mg CPNP +10 mg apramycin/kg (infected-CPNP +apramycin-treated) for 5 days.Results. The RT-qPCR analysis revealed different degrees of downregulation of all screened genes. Furthermore, the treatment of infected rabbits with CPNP or CPNP +apramycin significantly improved performance parameters, and total bacterial and Salmonella species counts, while also modulating both oxidative stress and altered liver and kidney parameters.Conclusion. This work demonstrates the use of CPNP alone or in combination with apramycin in the treatment of S. Typhimurium in rabbits." @default.
- W3203382021 created "2021-10-11" @default.
- W3203382021 creator A5011909197 @default.
- W3203382021 creator A5014207210 @default.
- W3203382021 creator A5018096632 @default.
- W3203382021 creator A5035385862 @default.
- W3203382021 creator A5039252240 @default.
- W3203382021 creator A5041122670 @default.
- W3203382021 creator A5069089411 @default.
- W3203382021 date "2021-10-06" @default.
- W3203382021 modified "2023-09-26" @default.
- W3203382021 title "Chitosan propolis nanocomposite alone or in combination with apramycin: an alternative therapy for multidrug-resistant Salmonella Typhimurium in rabbits: in vitro and in vivo study" @default.
- W3203382021 cites W1661812946 @default.
- W3203382021 cites W1718068934 @default.
- W3203382021 cites W195513463 @default.
- W3203382021 cites W1977290408 @default.
- W3203382021 cites W1977739800 @default.
- W3203382021 cites W1977771514 @default.
- W3203382021 cites W1989218256 @default.
- W3203382021 cites W1989690172 @default.
- W3203382021 cites W2008359948 @default.
- W3203382021 cites W2011992185 @default.
- W3203382021 cites W2020999936 @default.
- W3203382021 cites W2027558376 @default.
- W3203382021 cites W2048695976 @default.
- W3203382021 cites W2073589185 @default.
- W3203382021 cites W2090913604 @default.
- W3203382021 cites W2103517584 @default.
- W3203382021 cites W2121836743 @default.
- W3203382021 cites W2129345312 @default.
- W3203382021 cites W2138167687 @default.
- W3203382021 cites W2165178639 @default.
- W3203382021 cites W2329756632 @default.
- W3203382021 cites W2343328130 @default.
- W3203382021 cites W2431426158 @default.
- W3203382021 cites W2463750422 @default.
- W3203382021 cites W2554088124 @default.
- W3203382021 cites W2607787413 @default.
- W3203382021 cites W2751673642 @default.
- W3203382021 cites W2765470504 @default.
- W3203382021 cites W2797369678 @default.
- W3203382021 cites W2885805685 @default.
- W3203382021 cites W2915939486 @default.
- W3203382021 cites W2959342142 @default.
- W3203382021 cites W2973289059 @default.
- W3203382021 cites W2978065364 @default.
- W3203382021 cites W2996409978 @default.
- W3203382021 cites W3011354595 @default.
- W3203382021 cites W3115613160 @default.
- W3203382021 cites W3143959600 @default.
- W3203382021 cites W4212853098 @default.
- W3203382021 doi "https://doi.org/10.1099/jmm.0.001412" @default.
- W3203382021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34612810" @default.
- W3203382021 hasPublicationYear "2021" @default.
- W3203382021 type Work @default.
- W3203382021 sameAs 3203382021 @default.
- W3203382021 citedByCount "5" @default.
- W3203382021 countsByYear W32033820212021 @default.
- W3203382021 countsByYear W32033820212022 @default.
- W3203382021 countsByYear W32033820212023 @default.
- W3203382021 crossrefType "journal-article" @default.
- W3203382021 hasAuthorship W3203382021A5011909197 @default.
- W3203382021 hasAuthorship W3203382021A5014207210 @default.
- W3203382021 hasAuthorship W3203382021A5018096632 @default.
- W3203382021 hasAuthorship W3203382021A5035385862 @default.
- W3203382021 hasAuthorship W3203382021A5039252240 @default.
- W3203382021 hasAuthorship W3203382021A5041122670 @default.
- W3203382021 hasAuthorship W3203382021A5069089411 @default.
- W3203382021 hasConcept C133936738 @default.
- W3203382021 hasConcept C150903083 @default.
- W3203382021 hasConcept C185592680 @default.
- W3203382021 hasConcept C207001950 @default.
- W3203382021 hasConcept C2780488879 @default.
- W3203382021 hasConcept C2781065037 @default.
- W3203382021 hasConcept C31903555 @default.
- W3203382021 hasConcept C4937899 @default.
- W3203382021 hasConcept C501593827 @default.
- W3203382021 hasConcept C523546767 @default.
- W3203382021 hasConcept C54355233 @default.
- W3203382021 hasConcept C86803240 @default.
- W3203382021 hasConcept C89423630 @default.
- W3203382021 hasConceptScore W3203382021C133936738 @default.
- W3203382021 hasConceptScore W3203382021C150903083 @default.
- W3203382021 hasConceptScore W3203382021C185592680 @default.
- W3203382021 hasConceptScore W3203382021C207001950 @default.
- W3203382021 hasConceptScore W3203382021C2780488879 @default.
- W3203382021 hasConceptScore W3203382021C2781065037 @default.
- W3203382021 hasConceptScore W3203382021C31903555 @default.
- W3203382021 hasConceptScore W3203382021C4937899 @default.
- W3203382021 hasConceptScore W3203382021C501593827 @default.
- W3203382021 hasConceptScore W3203382021C523546767 @default.
- W3203382021 hasConceptScore W3203382021C54355233 @default.
- W3203382021 hasConceptScore W3203382021C86803240 @default.
- W3203382021 hasConceptScore W3203382021C89423630 @default.
- W3203382021 hasIssue "10" @default.
- W3203382021 hasLocation W32033820211 @default.
- W3203382021 hasLocation W32033820212 @default.
- W3203382021 hasOpenAccess W3203382021 @default.
- W3203382021 hasPrimaryLocation W32033820211 @default.
- W3203382021 hasRelatedWork W118525005 @default.