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- W3203399033 abstract "Presented herein is a one-pot cascade reaction of o-alkynylnitrobenzenes with maleimides leading to the formation of hydroxysuccinimide substituted indolin-3-ones under Au(III)-Cu(II) relay/synergetic catalysis. Mechanistically, the formation of the title products involves an unprecedented cascade process including (1) nitro-alkyne cycloisomerization of o-alkynylnitrobenzene to give isatogen; (2) [3 + 2] dipolar cycloaddition of isatogen with maleimide; and (3) ring opening of the in situ formed isoxazolidine moiety under neutral conditions. Notably, a wide range of substrates bearing various functional groups are compatible with the reaction conditions to give a series of highly valuable hybrid compounds in good efficiency with excellent atom economy. In addition, the products thus obtained could be easily transformed into the corresponding maleimide substituted indolin-3-ones. Importantly, some products demonstrated significant antiproliferative activity in human cancer cell lines." @default.
- W3203399033 created "2021-10-11" @default.
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- W3203399033 date "2021-09-30" @default.
- W3203399033 modified "2023-09-26" @default.
- W3203399033 title "Synthesis of Hydroxysuccinimide Substituted Indolin-3-ones via One-Pot Cascade Reaction of <i>o</i>-Alkynylnitrobenzenes with Maleimides under Au(III)–Cu(II) Relay/Synergetic Catalysis" @default.
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- W3203399033 doi "https://doi.org/10.1021/acs.joc.1c01485" @default.
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