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• W3203411532 endingPage "155704" @default.
• W3203411532 startingPage "155704" @default.
• W3203411532 abstract "Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life. Cytokines and chemokines contribute to this dynamic immune signaling network and can be altered by many factors, such as infection. Newborns undergo dynamic changes important to health and disease, yet there is limited information regarding human neonatal plasma cytokine and chemokine concentrations over the first week of life. The few available studies are limited by small sample size, cross-sectional study design, or focus on perturbed host states like severe infection or prematurity. To characterize immune ontogeny among healthy full-term newborns, we assessed plasma cytokine and chemokine concentrations across the first week of life in a robust longitudinal cohort of healthy, full-term African newborns.We analyzed a subgroup of a cohort of healthy newborns at the Medical Research Council Unit in The Gambia (West Africa; N = 608). Peripheral blood plasma was collected from all study participants at birth (day of life (DOL) 0) and at one follow-up time point at DOL 1, 3, or 7. Plasma cytokine and chemokine concentrations were measured by bead-based cytokine multiplex assay. Unsupervised clustering was used to identify patterns in plasma cytokine and chemokine ontogeny during early life.We observed an increase across the first week of life in plasma Th1 cytokines such as IFNγ and CXCL10 and a decrease in Th2 and anti-inflammatory cytokines such as IL-6 and IL-10, and chemokines such as CXCL8. In contrast, other cytokines and chemokines (e.g. IL-4 and CCL5, respectively) remained unchanged during the first week of life. This robust ontogenetic pattern did not appear to be affected by gestational age or sex.Ontogeny is a strong driver of newborn plasma-based levels of cytokines and chemokines throughout the first week of life with a rising IFNγ axis suggesting post-natal upregulation of host defense pathways. Our study will prove useful to the design and interpretation of future studies aimed at understanding the neonatal immune system during health and disease." @default.
• W3203411532 created "2021-10-11" @default.
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• W3203411532 date "2021-12-01" @default.
• W3203411532 modified "2023-09-26" @default.
• W3203411532 title "Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life" @default.
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• W3203411532 cites W1948268265 @default.
• W3203411532 cites W1963741468 @default.
• W3203411532 cites W1967052290 @default.
• W3203411532 cites W1970032996 @default.
• W3203411532 cites W1972629692 @default.
• W3203411532 cites W1973085561 @default.
• W3203411532 cites W1977997567 @default.
• W3203411532 cites W1981707679 @default.
• W3203411532 cites W1989287758 @default.
• W3203411532 cites W1989579799 @default.
• W3203411532 cites W1989969671 @default.
• W3203411532 cites W1993271798 @default.
• W3203411532 cites W1995269246 @default.
• W3203411532 cites W2015199010 @default.
• W3203411532 cites W2030067400 @default.
• W3203411532 cites W2033728890 @default.
• W3203411532 cites W2037116667 @default.
• W3203411532 cites W2062087063 @default.
• W3203411532 cites W2087072867 @default.
• W3203411532 cites W2091977122 @default.
• W3203411532 cites W2096150641 @default.
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• W3203411532 cites W2103865995 @default.
• W3203411532 cites W2107092366 @default.
• W3203411532 cites W2108040296 @default.
• W3203411532 cites W2115462905 @default.
• W3203411532 cites W2119347566 @default.
• W3203411532 cites W2124524947 @default.
• W3203411532 cites W2129239355 @default.
• W3203411532 cites W2134575990 @default.
• W3203411532 cites W2139567064 @default.
• W3203411532 cites W2139657682 @default.
• W3203411532 cites W2171748573 @default.
• W3203411532 cites W2296903341 @default.
• W3203411532 cites W2298077113 @default.
• W3203411532 cites W2302860934 @default.
• W3203411532 cites W2304521922 @default.
• W3203411532 cites W2313144233 @default.
• W3203411532 cites W2336656712 @default.
• W3203411532 cites W2344645165 @default.
• W3203411532 cites W2517700447 @default.
• W3203411532 cites W2518536270 @default.
• W3203411532 cites W2547214152 @default.
• W3203411532 cites W2565277080 @default.
• W3203411532 cites W2599501186 @default.
• W3203411532 cites W2600575351 @default.
• W3203411532 cites W2752607195 @default.
• W3203411532 cites W2770741845 @default.
• W3203411532 cites W2772231960 @default.
• W3203411532 cites W2804737546 @default.
• W3203411532 cites W2896481903 @default.
• W3203411532 cites W2910665890 @default.
• W3203411532 cites W2910765752 @default.
• W3203411532 cites W2912905681 @default.
• W3203411532 cites W2916394687 @default.
• W3203411532 cites W2921574129 @default.
• W3203411532 cites W2925943906 @default.
• W3203411532 cites W2953176680 @default.
• W3203411532 cites W2983520741 @default.
• W3203411532 cites W2999754765 @default.
• W3203411532 cites W3009606352 @default.
• W3203411532 cites W3009920944 @default.
• W3203411532 cites W3015830199 @default.
• W3203411532 cites W3023084813 @default.
• W3203411532 cites W3092967281 @default.
• W3203411532 cites W3093093332 @default.
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• W3203411532 doi "https://doi.org/10.1016/j.cyto.2021.155704" @default.
• W3203411532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34597920" @default.
• W3203411532 hasPublicationYear "2021" @default.
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