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• W3203431640 abstract "Abstract Microbial exposures are crucial environmental factors that impact healthspan by sculpting the immune system and microbiota. Antibody profiling via programmable Phage ImmunoPrecipitation Sequencing (PhIP-Seq) provides a high-throughput, costeffective approach for multiplexed detection of exposure and response to thousands of microbial protein products. Here we designed and constructed a library of 95,601 56 amino acid peptide tiles spanning a subset of environmental proteins more likely to be associated with immune responses: those with “toxin” or “virulence factor” keyword annotations. PhIP-Seq was used to profile the circulating antibodies of ~1,000 individuals against this “ToxScan” library of 14,430 toxins and virulence factors from 1,312 genera of organisms. In addition to a detailed analysis of six commonly encountered human commensals and pathogens, we study the age-dependent stability of the ToxScan profile and use a genome-wide association study (GWAS) to find that the MHC-II locus modulates the selection of bacterial epitopes. We detect previously described anti-flagellin antibody responses in a Crohn’s disease cohort and identify a novel association between anti-flagellin antibodies and juvenile dermatomyositis (JDM). PhIP-Seq with the ToxScan library provides a new window into exposure and immune responses to environmental protein toxins and virulence factors, which can be used to study human health and disease at cohort scale." @default.
• W3203431640 created "2021-10-11" @default.
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• W3203431640 date "2021-10-02" @default.
• W3203431640 modified "2023-10-18" @default.
• W3203431640 title "Prevalence, persistence, and genetics of antibody responses to protein toxins and virulence factors" @default.
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• W3203431640 doi "https://doi.org/10.1101/2021.10.01.462481" @default.
• W3203431640 hasPublicationYear "2021" @default.
• W3203431640 type Work @default.
• W3203431640 sameAs 3203431640 @default.

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