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- W3203446118 abstract "Early-onset neonatal sepsis can increase the risk of hypoxic-ischemic encephalopathy (HIE) that can worsen the patient’s prognosis. We investigated neurometabolic coupling (NMC) in five full-term neonates with HIE and sepsis that was found lower than the other five with HIE only. We hypothesized that transcranial photobiomodulation might upregulate cerebral oxygen metabolism, which may restore NMC. We developed a human brain organoid platform to evaluate the effects of photobiomodulation around 810 nm on the Cytochrome-C Oxidase (CCO) activity and electrophysiology. We found that 10 min of photobiomodulation increased CCO activity, pH, and temperature while decreased the spectral exponent in 1–40 Hz from electrophysiology data. For future work, it is postulated that photobiomodulation at ~810 nm may ameliorate metabolic acidosis and dysfunctional NMC in neonatal sepsis, thereby reducing the risk of HIE transition." @default.
- W3203446118 created "2021-10-11" @default.
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- W3203446118 date "2021-10-02" @default.
- W3203446118 modified "2023-10-01" @default.
- W3203446118 title "Human Brain Organoid Platform for Neuroengineering Optical Theranostics in Neonatal Sepsis" @default.
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- W3203446118 doi "https://doi.org/10.1007/978-3-030-70316-5_120" @default.
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