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- W3203449249 abstract "It is a great challenge to endow the bioceramics with the bone-matched mechanical performances. Here, capturing inspiration from well ordered-microstructures in the high-performance natural composites, we propose a universal biomineralization-assembly-sintering approach for the fabrication of well ordered-microstructure meta-hydroxyapatite. Owing to the well ordered-microstructure and a new metal ions-related interface toughening mechanism, this well ordered-microstructure hydroxyapatite exhibits remarkable mechanical performances, which are far beyond those of existing hydroxyapatite-based bioceramic and totally matched with the human cortical bone. Furthermore, the ordered microstructure plays a significant role in modulating the cell fates and finally stimulating bone defects regeneration in vivo. This work not only provides a strategy for the fabrication of well ordered-microstructure bioceramic but also broadens the horizons for the interface toughening mechanism of composites and microstructure design of biomaterials for bone regeneration." @default.
- W3203449249 created "2021-10-11" @default.
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- W3203449249 date "2021-12-01" @default.
- W3203449249 modified "2023-10-06" @default.
- W3203449249 title "Well ordered-microstructure bioceramics" @default.
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- W3203449249 doi "https://doi.org/10.1016/j.apmt.2021.101194" @default.
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