FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203449849> ?p ?o ?g. }

• W3203449849 abstract "ABSTRACT The inability to detect early degenerative changes to the articular cartilage surface that commonly precede bulk osteoarthritic degradation is an obstacle to early disease detection for research or clinical diagnosis. Leveraging a known artifact that blurs tissue boundaries in clinical arthrograms, contrast agent diffusivity can be derived from computed tomography arthrography (CTa) scans. We combined experimental and computational approaches to study protocol variations that may alter the CTa-derived apparent diffusivity. In experimental studies on bovine cartilage explants, we examined how contrast agent dilution and transport direction (absorption vs. desorption) influence the apparent diffusivity of untreated and enzymatically digested cartilage. Using multiphysics simulations, we examined mechanisms underlying experimental observations and the effects of image resolution, scan interval and early scan termination. The apparent diffusivity during absorption decreased with increasing contrast agent concentration by an amount similar to the increase induced by tissue digestion. Models indicated that osmotically induced fluid efflux strongly contributed to the concentration effect. Simulated changes to spatial resolution, scan spacing and total scan time all influenced the apparent diffusivity, indicating the importance of consistent protocols. With careful control of imaging protocols and interpretations guided by transport models, CTa-derived diffusivity offers promise as a biomarker for early degenerative changes." @default.
• W3203449849 created "2021-10-11" @default.
• W3203449849 creator A5044405214 @default.
• W3203449849 creator A5053255214 @default.
• W3203449849 creator A5063020829 @default.
• W3203449849 creator A5087909997 @default.
• W3203449849 date "2021-10-02" @default.
• W3203449849 modified "2023-09-26" @default.
• W3203449849 title "Contrast Solution Properties and Scan Parameters Influence the Apparent Diffusivity of Computed Tomography Contrast Agents in Articular Cartilage" @default.
• W3203449849 cites W1580157778 @default.
• W3203449849 cites W1964872256 @default.
• W3203449849 cites W1970656189 @default.
• W3203449849 cites W1972523662 @default.
• W3203449849 cites W1976848578 @default.
• W3203449849 cites W1979233582 @default.
• W3203449849 cites W1982934551 @default.
• W3203449849 cites W1986363946 @default.
• W3203449849 cites W1990859263 @default.
• W3203449849 cites W1992173705 @default.
• W3203449849 cites W1993711449 @default.
• W3203449849 cites W2007696224 @default.
• W3203449849 cites W2010091461 @default.
• W3203449849 cites W2011038175 @default.
• W3203449849 cites W2012871942 @default.
• W3203449849 cites W2016992192 @default.
• W3203449849 cites W2017950984 @default.
• W3203449849 cites W2027441032 @default.
• W3203449849 cites W2031144025 @default.
• W3203449849 cites W2037245148 @default.
• W3203449849 cites W2040893494 @default.
• W3203449849 cites W2055978912 @default.
• W3203449849 cites W2057198306 @default.
• W3203449849 cites W2068891351 @default.
• W3203449849 cites W2070353556 @default.
• W3203449849 cites W2073572317 @default.
• W3203449849 cites W2082273415 @default.
• W3203449849 cites W2083182475 @default.
• W3203449849 cites W2088265279 @default.
• W3203449849 cites W2092282157 @default.
• W3203449849 cites W2126609373 @default.
• W3203449849 cites W2131907878 @default.
• W3203449849 cites W2133195919 @default.
• W3203449849 cites W2141678715 @default.
• W3203449849 cites W2153413679 @default.
• W3203449849 cites W2153522233 @default.
• W3203449849 cites W2154265816 @default.
• W3203449849 cites W2166553915 @default.
• W3203449849 cites W2218991378 @default.
• W3203449849 cites W2310893987 @default.
• W3203449849 cites W2521386967 @default.
• W3203449849 cites W2529696202 @default.
• W3203449849 cites W2729890352 @default.
• W3203449849 cites W2754049912 @default.
• W3203449849 cites W2797071843 @default.
• W3203449849 cites W2807946833 @default.
• W3203449849 cites W2809658395 @default.
• W3203449849 cites W2884421169 @default.
• W3203449849 cites W2916266454 @default.
• W3203449849 cites W2930300108 @default.
• W3203449849 cites W2960014112 @default.
• W3203449849 cites W2973571998 @default.
• W3203449849 cites W2977495963 @default.
• W3203449849 cites W2987039153 @default.
• W3203449849 cites W2989943878 @default.
• W3203449849 cites W3006376233 @default.
• W3203449849 cites W3034862096 @default.
• W3203449849 cites W3045546915 @default.
• W3203449849 doi "https://doi.org/10.1101/2021.10.01.462834" @default.
• W3203449849 hasPublicationYear "2021" @default.
• W3203449849 type Work @default.
• W3203449849 sameAs 3203449849 @default.
• W3203449849 citedByCount "1" @default.
• W3203449849 countsByYear W32034498492022 @default.
• W3203449849 crossrefType "posted-content" @default.
• W3203449849 hasAuthorship W3203449849A5044405214 @default.
• W3203449849 hasAuthorship W3203449849A5053255214 @default.
• W3203449849 hasAuthorship W3203449849A5063020829 @default.
• W3203449849 hasAuthorship W3203449849A5087909997 @default.
• W3203449849 hasBestOaLocation W32034498491 @default.
• W3203449849 hasConcept C105702510 @default.
• W3203449849 hasConcept C121332964 @default.
• W3203449849 hasConcept C136229726 @default.
• W3203449849 hasConcept C142724271 @default.
• W3203449849 hasConcept C154945302 @default.
• W3203449849 hasConcept C185544564 @default.
• W3203449849 hasConcept C185592680 @default.
• W3203449849 hasConcept C192562407 @default.
• W3203449849 hasConcept C204787440 @default.
• W3203449849 hasConcept C2776164576 @default.
• W3203449849 hasConcept C2776502983 @default.
• W3203449849 hasConcept C2778863792 @default.
• W3203449849 hasConcept C2779010991 @default.
• W3203449849 hasConcept C2780550940 @default.
• W3203449849 hasConcept C3020332539 @default.
• W3203449849 hasConcept C37668627 @default.
• W3203449849 hasConcept C41008148 @default.
• W3203449849 hasConcept C62520636 @default.
• W3203449849 hasConcept C71924100 @default.
• W3203449849 hasConceptScore W3203449849C105702510 @default.
• W3203449849 hasConceptScore W3203449849C121332964 @default.

• next