Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203450355> ?p ?o ?g. }
- W3203450355 endingPage "101037" @default.
- W3203450355 startingPage "101037" @default.
- W3203450355 abstract "The oxygen demands of the human body require the constant circulation of blood carrying an enormous concentration of hemoglobin (Hb). Oxygen transport depends not only on the amount of Hb, but also on the control over the affinity of the protein for the gas, which can be optimized for the environmental conditions by changes in the concentration of effectors (hydrogen ions, chloride, CO2, and DPG) inside the red cell. Some pathological conditions affecting Hb may benefit from pharmacological interventions to increase or decrease its affinity for oxygen, or otherwise modify its properties, or alter its biosynthesis. Examples of such conditions include sickle cell anemia, thalassemias and inherited hemoglobinopathies. Effective and safe drugs such as voxelotor, bezafibrate and efaproxiral are available that significantly increase or decrease Hb oxygen affinity. Some medical conditions not directly affecting the blood or its oxygen carrying capacity may also be relieved by the manipulation of Hb. For example, the standard treatment of acute cyanide poisoning requires the oxidation of a fraction of the Hb in the bloodstream so that it efficiently scavenges cyanide. Tumors are often extremely hypoxic and therefore strongly resistant to radiotherapy; the sensitivity of cancerous tissue to X-rays may be increased by improved oxygenation through drugs binding Hb. This review attempts to provide a systematic exploration of the pharmacology of Hb, its molecular basis, and its intended and possible uses." @default.
- W3203450355 created "2021-10-11" @default.
- W3203450355 creator A5013027895 @default.
- W3203450355 creator A5076021638 @default.
- W3203450355 date "2022-04-01" @default.
- W3203450355 modified "2023-10-17" @default.
- W3203450355 title "Hemoglobin allostery and pharmacology" @default.
- W3203450355 cites W138637601 @default.
- W3203450355 cites W1482468374 @default.
- W3203450355 cites W1502235800 @default.
- W3203450355 cites W1533180394 @default.
- W3203450355 cites W1570260878 @default.
- W3203450355 cites W1915111098 @default.
- W3203450355 cites W1969361812 @default.
- W3203450355 cites W1971205444 @default.
- W3203450355 cites W1971375797 @default.
- W3203450355 cites W1972681415 @default.
- W3203450355 cites W1972735584 @default.
- W3203450355 cites W1972919297 @default.
- W3203450355 cites W1973175248 @default.
- W3203450355 cites W1975773361 @default.
- W3203450355 cites W1981082470 @default.
- W3203450355 cites W1983979304 @default.
- W3203450355 cites W1986470917 @default.
- W3203450355 cites W1986605564 @default.
- W3203450355 cites W1993827281 @default.
- W3203450355 cites W1997440251 @default.
- W3203450355 cites W1998093640 @default.
- W3203450355 cites W2002437746 @default.
- W3203450355 cites W2003266780 @default.
- W3203450355 cites W2004194157 @default.
- W3203450355 cites W2004578534 @default.
- W3203450355 cites W2018875508 @default.
- W3203450355 cites W2021714857 @default.
- W3203450355 cites W2023939379 @default.
- W3203450355 cites W2023986358 @default.
- W3203450355 cites W2024191400 @default.
- W3203450355 cites W2026911129 @default.
- W3203450355 cites W2031427013 @default.
- W3203450355 cites W2031971485 @default.
- W3203450355 cites W2034758585 @default.
- W3203450355 cites W2037543287 @default.
- W3203450355 cites W2040223458 @default.
- W3203450355 cites W2043209324 @default.
- W3203450355 cites W2044466209 @default.
- W3203450355 cites W2050643839 @default.
- W3203450355 cites W2054838182 @default.
- W3203450355 cites W2055380355 @default.
- W3203450355 cites W2057952058 @default.
- W3203450355 cites W2058995893 @default.
- W3203450355 cites W2059029931 @default.
- W3203450355 cites W2066473104 @default.
- W3203450355 cites W2066949918 @default.
- W3203450355 cites W2075460586 @default.
- W3203450355 cites W2080673614 @default.
- W3203450355 cites W2082567777 @default.
- W3203450355 cites W2086405025 @default.
- W3203450355 cites W2087032325 @default.
- W3203450355 cites W2088475513 @default.
- W3203450355 cites W2089648056 @default.
- W3203450355 cites W2091053131 @default.
- W3203450355 cites W2091053357 @default.
- W3203450355 cites W2094751995 @default.
- W3203450355 cites W2117510107 @default.
- W3203450355 cites W2118791856 @default.
- W3203450355 cites W2119195368 @default.
- W3203450355 cites W2132023692 @default.
- W3203450355 cites W2148344613 @default.
- W3203450355 cites W2150368990 @default.
- W3203450355 cites W2155479284 @default.
- W3203450355 cites W2158987578 @default.
- W3203450355 cites W2165845627 @default.
- W3203450355 cites W2169568707 @default.
- W3203450355 cites W2170736271 @default.
- W3203450355 cites W230984257 @default.
- W3203450355 cites W2320546708 @default.
- W3203450355 cites W2327883350 @default.
- W3203450355 cites W2475019041 @default.
- W3203450355 cites W2538885384 @default.
- W3203450355 cites W2606899343 @default.
- W3203450355 cites W2754515811 @default.
- W3203450355 cites W2767601947 @default.
- W3203450355 cites W2767777576 @default.
- W3203450355 cites W2767911924 @default.
- W3203450355 cites W2785404304 @default.
- W3203450355 cites W2890197549 @default.
- W3203450355 cites W2905144349 @default.
- W3203450355 cites W2909832709 @default.
- W3203450355 cites W2911398658 @default.
- W3203450355 cites W2914004333 @default.
- W3203450355 cites W2963601024 @default.
- W3203450355 cites W2971070453 @default.
- W3203450355 cites W2982514380 @default.
- W3203450355 cites W3004846426 @default.
- W3203450355 cites W3005306837 @default.
- W3203450355 cites W3011621712 @default.
- W3203450355 cites W3012148201 @default.
- W3203450355 cites W3020925632 @default.