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- W3203451785 abstract "Nanotechnology has shown enhanced potential in multidisciplinary fields and has been an emerging area of research for decades. Cancer theranostics, a technology with a combined diagnostic and therapeutic impact, provides efficient drug delivery with enhanced targeting along with safe and efficient chemotherapy. Safety and toxicity are critical problems that need to be addressed for the successful clinical application of nanobiomaterials in cancer theranostics. The factors impacting the safety of nanobiomaterials include shape, size, surface charge, physiological fluids to which they are subjected, biocompatibility, dosage-related parameters, and exposure time. Zebrafish, a promising gold standard model for in vitro evaluation of toxicity of nanopharmaceuticals, can also be used for assessment of nanobiomaterials intended for the environment, health, and safety. Safe-by-design is an innovative approach proposed by scientists for managing the safety aspects of nanobiomaterials. It involves the use of various strategies like doping, coating, grafting, loading, optimizing size and shape, managing surface charge, reducing persistence and interaction, and passivating the defective site for safe production, development, and use of nanobiomaterials. It also helps in risk management to resolve uncertainty, indeterminacy, and design liability. The use of green nanobiomaterials is an emerging field which addresses safety toward the environment as well as human health. This chapter provides an overview of nanobiomaterials used in cancer theranostics, concept of safe-by-design strategy, toxicological studies, risk management, as well as emerging trends in the field of theranostics." @default.
- W3203451785 created "2021-10-11" @default.
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- W3203451785 date "2021-01-01" @default.
- W3203451785 modified "2023-09-23" @default.
- W3203451785 title "Safety of Nanobiomaterials for Cancer Nanotheranostics" @default.
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