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- W3203535868 abstract "In PNAS, Malonis et al. (1) isolate and characterize several human monoclonal antibodies (MoAbs) that neutralize infection with arthritogenic alphaviruses. Alphaviruses represent a large group of positive-strand RNA viruses, some of which cause infections in humans. They are widely distributed, are transmitted by mosquitoes, and have been clinically classified as encephalitic and arthritogenic, according to the most prevalent symptoms in human and animal infections. Among alphaviruses, Chikungunya virus (CHIKV) is a frequent cause of outbreaks in different geographic locations and is characterized by fever and joint inflammation, often accompanied by persistent joint pain and arthralgia for several months after initial infection that can lead to joint immobilization (2). CHIKV is transmitted by Aedes mosquitoes, and, although most infections take place in the tropical and subtropical regions, outbreaks and local transmission of CHIKV have been known to occur in Europe and the United States too. The expansion of the geographical distribution of the Aedes vector has been a major contributor to the increases in CHIKV infections during the last decades (3). Other arthritogenic alphaviruses known to infect humans are Mayaro virus (MAYV), Ross River virus (RRV), and O’nyong-nyong virus (ONNV), present in South America, the South Pacific, and Africa, respectively. Currently, despite their burden on human health, there are no available specific treatments or vaccines against any alphaviruses. The use of pathogen-specific … [↵][1]1 Email: adolfo.garcia-sastre{at}mssm.edu. [1]: #xref-corresp-1-1" @default.
- W3203535868 created "2021-10-11" @default.
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- W3203535868 date "2021-10-08" @default.
- W3203535868 modified "2023-10-18" @default.
- W3203535868 title "Genomics serology to inform therapies and vaccines for arthritogenic alphaviruses" @default.
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- W3203535868 doi "https://doi.org/10.1073/pnas.2114687118" @default.
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