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- W3203543531 abstract "Phospholipid ethers (PLE) provide an innovative approach to preferentially target cancer cells by capitalizing on their increased number/size of lipid rafts. PLE are designed to possess high affinity to lipid rafts which upon binding results in internalization and the ability to deliver an attached warhead to the cytosol. CLR 131 is a novel PLE conjugated to I-131, which was chosen due to its 8-day half-life and well-established efficacy in multiple cancer types. Preclinical/phase I data has shown CLR 131 to be preferentially taken up by cancer cells and to cross the blood brain barrier." @default.
- W3203543531 created "2021-10-11" @default.
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- W3203543531 date "2021-09-01" @default.
- W3203543531 modified "2023-10-18" @default.
- W3203543531 title "857TiP An open-label, multicenter, phase II study of CLR 131 in patients with relapsed or refractory (R/R) select B-cell malignancies (CLOVER-1) and expansion cohort in patients with waldenstrom macroglobulinemia (CLOVER-WaM)" @default.
- W3203543531 doi "https://doi.org/10.1016/j.annonc.2021.08.150" @default.
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