FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203551222> ?p ?o ?g. }

• W3203551222 endingPage "79" @default.
• W3203551222 startingPage "70" @default.
• W3203551222 abstract "Despite intense efforts to develop an objective diagnostic test for Parkinson's disease, there is still no consensus on biomarkers that can accurately diagnose the disease.Identification of biomarkers for idiopathic Parkinson's disease (PD) may enable accurate diagnosis of the disease. We tried to find molecular and cellular differences in dopaminergic (DA) neurons derived from healthy subjects and idiopathic PD patients with or without rest tremor at onset.We measured the expression of genes controlling dopamine synthesis, sequestration, and catabolism as well as the levels of corresponding metabolites and reactive oxygen species in midbrain DA neurons differentiated from induced pluripotent stem cells (iPSCs) of healthy subjects and PD patients with or without rest tremor.Significant differences in DA-related gene expression, metabolites, and oxidative stress were found between midbrain DA neurons derived from healthy subjects and patients with PD. DA neurons derived from PD patients with or without rest tremor at onset exhibited significant differences in the levels of some of these transcripts, metabolites, and oxidative stress.The unique combination of these quantifiable molecular and cellular traits in iPSC-derived midbrain DA neurons can distinguish healthy subjects from idiopathic PD patients and segregate PD patients with or without rest tremor at onset. The strategy may be used to develop an objective diagnostic test for PD." @default.
• W3203551222 created "2021-10-11" @default.
• W3203551222 creator A5005215105 @default.
• W3203551222 creator A5015200745 @default.
• W3203551222 creator A5015894942 @default.
• W3203551222 creator A5023229072 @default.
• W3203551222 creator A5027475930 @default.
• W3203551222 creator A5038069496 @default.
• W3203551222 creator A5041198839 @default.
• W3203551222 creator A5049204516 @default.
• W3203551222 creator A5066905895 @default.
• W3203551222 creator A5085554438 @default.
• W3203551222 date "2021-09-26" @default.
• W3203551222 modified "2023-10-02" @default.
• W3203551222 title "Molecular Features of Parkinson's Disease in Patient‐Derived Midbrain Dopaminergic Neurons" @default.
• W3203551222 cites W1507452489 @default.
• W3203551222 cites W1588910430 @default.
• W3203551222 cites W1945311586 @default.
• W3203551222 cites W1965114915 @default.
• W3203551222 cites W1969280474 @default.
• W3203551222 cites W1974200504 @default.
• W3203551222 cites W1984323435 @default.
• W3203551222 cites W1985419794 @default.
• W3203551222 cites W1987004867 @default.
• W3203551222 cites W1989703483 @default.
• W3203551222 cites W2010478595 @default.
• W3203551222 cites W2010947186 @default.
• W3203551222 cites W2027094797 @default.
• W3203551222 cites W2035121417 @default.
• W3203551222 cites W2059600528 @default.
• W3203551222 cites W2088189017 @default.
• W3203551222 cites W2103493168 @default.
• W3203551222 cites W2109852750 @default.
• W3203551222 cites W2112455323 @default.
• W3203551222 cites W2114431124 @default.
• W3203551222 cites W2115524468 @default.
• W3203551222 cites W2120853677 @default.
• W3203551222 cites W2125987139 @default.
• W3203551222 cites W2128399345 @default.
• W3203551222 cites W2130734362 @default.
• W3203551222 cites W2145954079 @default.
• W3203551222 cites W2149472336 @default.
• W3203551222 cites W2158511243 @default.
• W3203551222 cites W2161756416 @default.
• W3203551222 cites W2340402631 @default.
• W3203551222 cites W2410155707 @default.
• W3203551222 cites W2505865209 @default.
• W3203551222 cites W2611116575 @default.
• W3203551222 cites W2738881219 @default.
• W3203551222 cites W27428450 @default.
• W3203551222 cites W2791928525 @default.
• W3203551222 cites W2792171782 @default.
• W3203551222 cites W2914810762 @default.
• W3203551222 cites W2942299920 @default.
• W3203551222 cites W3004173642 @default.
• W3203551222 cites W37005 @default.
• W3203551222 doi "https://doi.org/10.1002/mds.28786" @default.
• W3203551222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34564901" @default.
• W3203551222 hasPublicationYear "2021" @default.
• W3203551222 type Work @default.
• W3203551222 sameAs 3203551222 @default.
• W3203551222 citedByCount "4" @default.
• W3203551222 countsByYear W32035512222022 @default.
• W3203551222 countsByYear W32035512222023 @default.
• W3203551222 crossrefType "journal-article" @default.
• W3203551222 hasAuthorship W3203551222A5005215105 @default.
• W3203551222 hasAuthorship W3203551222A5015200745 @default.
• W3203551222 hasAuthorship W3203551222A5015894942 @default.
• W3203551222 hasAuthorship W3203551222A5023229072 @default.
• W3203551222 hasAuthorship W3203551222A5027475930 @default.
• W3203551222 hasAuthorship W3203551222A5038069496 @default.
• W3203551222 hasAuthorship W3203551222A5041198839 @default.
• W3203551222 hasAuthorship W3203551222A5049204516 @default.
• W3203551222 hasAuthorship W3203551222A5066905895 @default.
• W3203551222 hasAuthorship W3203551222A5085554438 @default.
• W3203551222 hasBestOaLocation W32035512222 @default.
• W3203551222 hasConcept C126322002 @default.
• W3203551222 hasConcept C137183658 @default.
• W3203551222 hasConcept C169760540 @default.
• W3203551222 hasConcept C2776151105 @default.
• W3203551222 hasConcept C2779134260 @default.
• W3203551222 hasConcept C2779734285 @default.
• W3203551222 hasConcept C2781197716 @default.
• W3203551222 hasConcept C513476851 @default.
• W3203551222 hasConcept C529278444 @default.
• W3203551222 hasConcept C54355233 @default.
• W3203551222 hasConcept C552161191 @default.
• W3203551222 hasConcept C71924100 @default.
• W3203551222 hasConcept C86803240 @default.
• W3203551222 hasConceptScore W3203551222C126322002 @default.
• W3203551222 hasConceptScore W3203551222C137183658 @default.
• W3203551222 hasConceptScore W3203551222C169760540 @default.
• W3203551222 hasConceptScore W3203551222C2776151105 @default.
• W3203551222 hasConceptScore W3203551222C2779134260 @default.
• W3203551222 hasConceptScore W3203551222C2779734285 @default.
• W3203551222 hasConceptScore W3203551222C2781197716 @default.
• W3203551222 hasConceptScore W3203551222C513476851 @default.
• W3203551222 hasConceptScore W3203551222C529278444 @default.

• next