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- W3203553106 abstract "Spontaneous blood clotting in pulmonary circulation caused by thrombo-inflammation is one of the main mortality causes during the COVID-19 disease. Blood clotting leads to reduced pulmonary circulation and blood oxygenation. Lung inflammation can be evaluated with noninvasive diagnostic techniques. However, the correlation of the severity of the inflammation with the pulmonary blood flow has not been established. To address this question, in this work, we develop a multiscale model taking into account the interaction of a local model of thrombus growth with 1D hemodynamics in a vessel network. Flux reduction depending on the level of lung obstruction is evaluated. In particular, the model obtains that an obstruction level of 5% leads to a 12% reduction of blood flux. The suggested approach can be used to investigate the interaction of blood clotting and flow not only in the pulmonary network but also in other complex vessel networks." @default.
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- W3203553106 date "2021-09-27" @default.
- W3203553106 modified "2023-10-16" @default.
- W3203553106 title "Blood Clotting Decreases Pulmonary Circulation during the Coronavirus Disease" @default.
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- W3203553106 doi "https://doi.org/10.3390/math9192401" @default.
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