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- W3203585890 abstract "Traditional chemotherapeutic agents have been successfully used to treat cancers, although their many disadvantages include poor solubility, high dosage needs, severe side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting of cancer cells. In this study, Methotrexate (MEX) and curcumin (CUR) were incorporated into the triblock copolymer poly(lactic-co-glycolic acid) (PLGA)–poly(ethylene glycol) (PEG)–PLGA to achieve synergism in the treatment of colorectal cancer. Nanoparticle-based combination treatments for colorectal cancer can be developed using this remarkably symmetric synthetic strategy. The particles were visualized by high-resolution transmission microscopy (HR-TEM), and their size and polydispersity were determined using dynamic light scattering. Without a blast of impact, MEX and CUR were released gently from the polymeric nanoparticle system. CUR/[email protected] also demonstrated dose-dependent cytotoxic effects on SW1417 and CL40 cell lines, with a higher apoptosis ratio than free MEX and CUR. According to the in vitro cellular uptake analysis, cancer cells absorbed the polymeric nanoparticles more readily. From the fluorescence experiment, nanomaterials promoted cell death in the SW1417 and CL40 cell lines. Additionally, in vivo systemic toxicity and in vitro findings support the biocompatibility of CUR/[email protected] Furthermore, these nanomaterials cause apoptosis in cancer cells. From these findings, CUR/[email protected] exhibit the potential to be successfully utilized to treat colorectal cancer." @default.
- W3203585890 created "2021-10-11" @default.
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- W3203585890 date "2021-12-01" @default.
- W3203585890 modified "2023-10-17" @default.
- W3203585890 title "Engineering of anticancer drugs entrapped polymeric nanoparticles for the treatment of colorectal cancer therapy" @default.
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- W3203585890 doi "https://doi.org/10.1016/j.procbio.2021.09.013" @default.
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