Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203608032> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3203608032 endingPage "167" @default.
- W3203608032 startingPage "152" @default.
- W3203608032 abstract "Background: The incidence and mortality of cancer are rapidly growing worldwide. Modification on drug delivery systems based on nanotechnology was applied to improve the effectiveness and safety of treatment. Nanoencapsulation, a part of nanotechnology, was known can be involved in cytotoxic agents. Objective: This research was conducted to determine the type of polymers for nanoencapsulation of cytotoxic agents and analyze the effect of nanoencapsulation on the cytotoxic activity. Methods: The study was performed by systematic literature review using selected articles from reputable databases that meet the inclusion and exclusion criteria. Results: The results show that many cytotoxic agents have been developed in nanocapsules systems due to their low water solubility, chemical instability, and low bioavailability. The nanoencapsulation process was carried out using synthetic or natural polymers such as polylactic-co-glycolic acid (PLGA), PEGylated PLGA, polycaprolactone (PCL), chitosan-sodium tripolyphosphate, chitosan-sodium alginate, heparin-poly(l-lysine), and polymethyl methacrylate (PMMA). Those polymers are widely used for nanoencapsulation related to their biocompatible, biodegradable, non-toxic, and providing the desired coating properties. The nanoencapsulation on cytotoxic agents significantly increases the in vitro cytotoxicity, marked by the decrease of IC50 value in the range 1.4-15.4 folds compared to pure drugs. The increase in cytotoxicity could be caused by particle size reduction, modification of particle surface properties, and enhancement of drug stability. Conclusion: It can be concluded that nanoencapsulation can be applied for cytotoxic agents to increase their activity using the appropriate coating polymer." @default.
- W3203608032 created "2021-10-11" @default.
- W3203608032 creator A5030264687 @default.
- W3203608032 creator A5030694593 @default.
- W3203608032 creator A5076812077 @default.
- W3203608032 creator A5080187441 @default.
- W3203608032 creator A5087003916 @default.
- W3203608032 date "2021-10-04" @default.
- W3203608032 modified "2023-09-24" @default.
- W3203608032 title "Development of Nanocapsules Containing Cytotoxic Agents- A Review" @default.
- W3203608032 doi "https://doi.org/10.22487/j24428744.2021.v7.i2.15578" @default.
- W3203608032 hasPublicationYear "2021" @default.
- W3203608032 type Work @default.
- W3203608032 sameAs 3203608032 @default.
- W3203608032 citedByCount "0" @default.
- W3203608032 crossrefType "journal-article" @default.
- W3203608032 hasAuthorship W3203608032A5030264687 @default.
- W3203608032 hasAuthorship W3203608032A5030694593 @default.
- W3203608032 hasAuthorship W3203608032A5076812077 @default.
- W3203608032 hasAuthorship W3203608032A5080187441 @default.
- W3203608032 hasAuthorship W3203608032A5087003916 @default.
- W3203608032 hasBestOaLocation W32036080321 @default.
- W3203608032 hasConcept C109316439 @default.
- W3203608032 hasConcept C155672457 @default.
- W3203608032 hasConcept C159985019 @default.
- W3203608032 hasConcept C171250308 @default.
- W3203608032 hasConcept C178790620 @default.
- W3203608032 hasConcept C181389837 @default.
- W3203608032 hasConcept C185592680 @default.
- W3203608032 hasConcept C192562407 @default.
- W3203608032 hasConcept C202751555 @default.
- W3203608032 hasConcept C204399865 @default.
- W3203608032 hasConcept C21951064 @default.
- W3203608032 hasConcept C2778551929 @default.
- W3203608032 hasConcept C2779732960 @default.
- W3203608032 hasConcept C2779820397 @default.
- W3203608032 hasConcept C2780165375 @default.
- W3203608032 hasConcept C521977710 @default.
- W3203608032 hasConcept C55493867 @default.
- W3203608032 hasConcept C71924100 @default.
- W3203608032 hasConcept C98274493 @default.
- W3203608032 hasConceptScore W3203608032C109316439 @default.
- W3203608032 hasConceptScore W3203608032C155672457 @default.
- W3203608032 hasConceptScore W3203608032C159985019 @default.
- W3203608032 hasConceptScore W3203608032C171250308 @default.
- W3203608032 hasConceptScore W3203608032C178790620 @default.
- W3203608032 hasConceptScore W3203608032C181389837 @default.
- W3203608032 hasConceptScore W3203608032C185592680 @default.
- W3203608032 hasConceptScore W3203608032C192562407 @default.
- W3203608032 hasConceptScore W3203608032C202751555 @default.
- W3203608032 hasConceptScore W3203608032C204399865 @default.
- W3203608032 hasConceptScore W3203608032C21951064 @default.
- W3203608032 hasConceptScore W3203608032C2778551929 @default.
- W3203608032 hasConceptScore W3203608032C2779732960 @default.
- W3203608032 hasConceptScore W3203608032C2779820397 @default.
- W3203608032 hasConceptScore W3203608032C2780165375 @default.
- W3203608032 hasConceptScore W3203608032C521977710 @default.
- W3203608032 hasConceptScore W3203608032C55493867 @default.
- W3203608032 hasConceptScore W3203608032C71924100 @default.
- W3203608032 hasConceptScore W3203608032C98274493 @default.
- W3203608032 hasIssue "2" @default.
- W3203608032 hasLocation W32036080321 @default.
- W3203608032 hasOpenAccess W3203608032 @default.
- W3203608032 hasPrimaryLocation W32036080321 @default.
- W3203608032 hasRelatedWork W2005711997 @default.
- W3203608032 hasRelatedWork W2082811360 @default.
- W3203608032 hasRelatedWork W2100809064 @default.
- W3203608032 hasRelatedWork W2594901353 @default.
- W3203608032 hasRelatedWork W2607401722 @default.
- W3203608032 hasRelatedWork W2791467515 @default.
- W3203608032 hasRelatedWork W2982016330 @default.
- W3203608032 hasRelatedWork W3002592311 @default.
- W3203608032 hasRelatedWork W3023266727 @default.
- W3203608032 hasRelatedWork W4245364193 @default.
- W3203608032 hasVolume "7" @default.
- W3203608032 isParatext "false" @default.
- W3203608032 isRetracted "false" @default.
- W3203608032 magId "3203608032" @default.
- W3203608032 workType "article" @default.