FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203609206> ?p ?o ?g. }

• W3203609206 abstract "The anaphase-promoting complex/cyclosome (APC/C) marks key cell cycle proteins for proteasomal breakdown, thereby ensuring unidirectional progression through the cell cycle. Its target recognition is temporally regulated by activating subunits, one of which is called CELL CYCLE SWITCH 52 A2 (CCS52A2). We sought to expand the knowledge of identified APC/C targets by using the severe growth phenotypes of CCS52A2-deficient Arabidopsis thaliana plants as a readout in a suppressor mutagenesis screen, resulting in the identification of the previously undescribed gene called PIKMIN1 (PKN1). PKN1 deficiency rescues the disorganized root stem cell phenotype of the ccs52a2-1 mutant, whereas an excess of PKN1 inhibits growth of ccs52a2-1 plants, indicating the importance of PKN1 abundance for proper development. Accordingly, the lack of PKN1 in a wild-type background negatively impacts cell division, while its ectopic expression promotes proliferation. PKN1 shows a cell cycle phase-dependent accumulation pattern, localizing to microtubular structures, including the preprophase band, the mitotic spindle, and phragmoplast. PKN1 is conserved throughout the plant kingdom, with its function in cell division being evolutionary conserved in the liverwort Marchantia polymorpha. Our data thus demonstrate that PKN1 represents a novel, plant-specific gene with a rate-limiting role in cell division, which is proteolytically controlled by the CCS52A2-activated APC/C." @default.
• W3203609206 created "2021-10-11" @default.
• W3203609206 creator A5006392310 @default.
• W3203609206 creator A5017299073 @default.
• W3203609206 creator A5017997996 @default.
• W3203609206 creator A5033845766 @default.
• W3203609206 creator A5055579028 @default.
• W3203609206 creator A5059792935 @default.
• W3203609206 creator A5065631149 @default.
• W3203609206 date "2021-09-28" @default.
• W3203609206 modified "2023-09-24" @default.
• W3203609206 title "The APC/CCCS52A2 E3-Ligase Complex targeted PKN1 Protein is a Plant Lineage-Specific Driver of Cell Division" @default.
• W3203609206 cites W1435488225 @default.
• W3203609206 cites W1592870802 @default.
• W3203609206 cites W1734706036 @default.
• W3203609206 cites W1892406518 @default.
• W3203609206 cites W1979212911 @default.
• W3203609206 cites W1983024157 @default.
• W3203609206 cites W1990769894 @default.
• W3203609206 cites W1991758259 @default.
• W3203609206 cites W1992030765 @default.
• W3203609206 cites W1992048328 @default.
• W3203609206 cites W1992313362 @default.
• W3203609206 cites W1993554114 @default.
• W3203609206 cites W1995405908 @default.
• W3203609206 cites W1995829416 @default.
• W3203609206 cites W1996146208 @default.
• W3203609206 cites W2002217310 @default.
• W3203609206 cites W2018811488 @default.
• W3203609206 cites W2022785470 @default.
• W3203609206 cites W2028185453 @default.
• W3203609206 cites W2029069158 @default.
• W3203609206 cites W2033066933 @default.
• W3203609206 cites W2042270773 @default.
• W3203609206 cites W2046986607 @default.
• W3203609206 cites W2060687391 @default.
• W3203609206 cites W2063985242 @default.
• W3203609206 cites W2064147590 @default.
• W3203609206 cites W2068783334 @default.
• W3203609206 cites W2080992349 @default.
• W3203609206 cites W2086243344 @default.
• W3203609206 cites W2087328424 @default.
• W3203609206 cites W2093278894 @default.
• W3203609206 cites W2098115340 @default.
• W3203609206 cites W2098446798 @default.
• W3203609206 cites W2108722324 @default.
• W3203609206 cites W2109579035 @default.
• W3203609206 cites W2109668181 @default.
• W3203609206 cites W2110402650 @default.
• W3203609206 cites W2110695808 @default.
• W3203609206 cites W2114070867 @default.
• W3203609206 cites W2114121640 @default.
• W3203609206 cites W2116122104 @default.
• W3203609206 cites W2118221662 @default.
• W3203609206 cites W2123952745 @default.
• W3203609206 cites W2126982845 @default.
• W3203609206 cites W2128013877 @default.
• W3203609206 cites W2129480177 @default.
• W3203609206 cites W2131510173 @default.
• W3203609206 cites W2142192445 @default.
• W3203609206 cites W2143097123 @default.
• W3203609206 cites W2145475128 @default.
• W3203609206 cites W2146341019 @default.
• W3203609206 cites W2147175477 @default.
• W3203609206 cites W2150123812 @default.
• W3203609206 cites W2152325672 @default.
• W3203609206 cites W2162680148 @default.
• W3203609206 cites W2162839658 @default.
• W3203609206 cites W2166987747 @default.
• W3203609206 cites W2167340357 @default.
• W3203609206 cites W2171018097 @default.
• W3203609206 cites W2295174916 @default.
• W3203609206 cites W2336936416 @default.
• W3203609206 cites W2338721912 @default.
• W3203609206 cites W2404247122 @default.
• W3203609206 cites W2466672815 @default.
• W3203609206 cites W2472633990 @default.
• W3203609206 cites W2544684770 @default.
• W3203609206 cites W2734610804 @default.
• W3203609206 cites W2765380711 @default.
• W3203609206 cites W2767701826 @default.
• W3203609206 cites W2768878155 @default.
• W3203609206 cites W280702633 @default.
• W3203609206 cites W2901332489 @default.
• W3203609206 cites W2911288916 @default.
• W3203609206 cites W2944164074 @default.
• W3203609206 cites W2945219515 @default.
• W3203609206 cites W2963112370 @default.
• W3203609206 cites W3011068807 @default.
• W3203609206 cites W3014320499 @default.
• W3203609206 cites W3044812815 @default.
• W3203609206 cites W3088344594 @default.
• W3203609206 cites W3094450900 @default.
• W3203609206 doi "https://doi.org/10.1101/2021.09.27.462019" @default.
• W3203609206 hasPublicationYear "2021" @default.
• W3203609206 type Work @default.
• W3203609206 sameAs 3203609206 @default.
• W3203609206 citedByCount "0" @default.
• W3203609206 crossrefType "posted-content" @default.
• W3203609206 hasAuthorship W3203609206A5006392310 @default.

• next