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• W3203611197 abstract "I read the article by Krittanawong et al1Krittanawong C Narasimhan B Wang Z et al.Association between egg consumption and risk of cardiovascular outcomes: a systematic review and meta-analysis.Am J Med. 2021; 134: 76-83.e2Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar with interest. The authors conducted a meta-analysis in the relationship between egg consumption and cardiovascular disease risk. Pooled hazard ratios (HRs; 95% confidence intervals [CIs]) of egg consumption of more than 1 egg per day for overall cardiovascular events and coronary artery disease were 0.99 (0.93-1.06) and 0.89 (0.86-0.93), respectively. I have some comments with special reference to sex difference and type of cardiovascular disease. Chen et al2Chen GC Chen LH Mossavar-Rahmani Y et al.Dietary cholesterol and egg intake in relation to incident cardiovascular disease and all-cause and cause-specific mortality in postmenopausal women.Am J Clin Nutr. 2021; 113: 948-959Crossref PubMed Scopus (2) Google Scholar reported that higher intakes of eggs and cholesterol were associated with a modestly elevated risk of the development of cardiovascular disease and all-cause and cardiovascular mortality in postmenopausal women. Regarding sex difference, Zhong et al3Zhong VW Van Horn L Cornelis MC et al.Associations of dietary cholesterol or egg consumption with incident cardiovascular disease and mortality.JAMA. 2019; 321: 1081-1095Crossref PubMed Scopus (137) Google Scholar conducted a long-term cohort study by targeting middle-aged subjects, and the positive association of dietary egg and cholesterol consumption with incident cardiovascular disease and all-cause mortality was stronger in women than that in men. In contrast, Zhuang et al4Zhuang P Wu F Mao L et al.Egg and cholesterol consumption and mortality from cardiovascular and different causes in the United States: A population-based cohort study.PLoS Med. 2021; 18e1003508Crossref PubMed Google Scholar conducted a cohort study by targeting women and men, with mean age of 62.2 years, at the baseline, and the positive association of dietary egg and cholesterol consumption with all-cause and cardiovascular disease mortality was stronger in men than that in women. Risk estimation for the incident cardiovascular disease and mortality, stratified by sex, should be made by the intervention study with appropriate setting of the control group. In any case, there is a risk of cardiovascular disease by higher egg consumption, which is different from data by Krittanawong et al.1Krittanawong C Narasimhan B Wang Z et al.Association between egg consumption and risk of cardiovascular outcomes: a systematic review and meta-analysis.Am J Med. 2021; 134: 76-83.e2Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar In addition, Chen et al2Chen GC Chen LH Mossavar-Rahmani Y et al.Dietary cholesterol and egg intake in relation to incident cardiovascular disease and all-cause and cause-specific mortality in postmenopausal women.Am J Clin Nutr. 2021; 113: 948-959Crossref PubMed Scopus (2) Google Scholar also presented the risk reduction of incident hemorrhagic stroke by taking the highest quintile of cholesterol intake, presenting HR (95% CI) of 0.69 (0.49-0.99). In contrast, Abdollahi et al5Abdollahi AM Virtanen HEK Voutilainen S et al.Egg consumption, cholesterol intake, and risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.Am J Clin Nutr. 2019; 110: 169-176Crossref PubMed Scopus (16) Google Scholar reported that HR (95% CI) of taking the highest quartile of cholesterol and egg consumption for incident hemorrhagic stroke in men was 1.10 (0.45-2.66) and 0.75 (0.32-1.77), respectively. Stratified analyses by sex and subtypes of cardiovascular disease and dose-response relationship between egg consumption and cardiovascular disease risk are needed to verify the association" @default.
• W3203611197 created "2021-10-11" @default.
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• W3203611197 date "2021-10-01" @default.
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• W3203611197 title "Higher Egg Consumption and Cardiovascular Risk" @default.
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• W3203611197 doi "https://doi.org/10.1016/j.amjmed.2021.05.025" @default.
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