Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203619485> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3203619485 abstract "Osteosarcoma (OSA) is associated with unfavorable prognosis. The overall survival rate for patients with OSA recurrence or metastasis is only about 20%. Long non-coding RNAs (lncRNAs) significantly function in gene expression and the progression of various cancers including OSA.The expression of repulsive guidance molecule BMP co-receptor b antisense RNA 1 (RGMB-AS1) was detected in OSA cells via qRT-PCR. Western blot assay exposed the protein level of ankyrin repeat domain 1 (ANKRD1). The function assays showed the role of RGMB-AS1, miR-3614-5p, ANKRD1 on OSA cell proliferation and invasion. Subcellular Fraction assay was conducted to detect RGMB-AS1 localization. Rescue assays manifested the mechanism of RGMB-AS1/miR-3614-5p/ANKRD1 axis in OSA cells.FOXA1-activated RGMB-AS1 positively regulated OSA cell progression including proliferation and invasion but negatively modulated apoptosis. miR-3614-5p interacted with RGMB-AS1 and functioned as the tumor suppressor in OSA cells. ANKRD1 was targeted by miR-3614-5p and was negatively interacted by miR-3614-5p. RGMB-AS1 and ANKRD1 competitively bound with miR-3614-5p. The suppression of silencing RGMB-AS1 on OSA cell progression was rescued by ANKRD1 overexpression or miR-3614-5p down-regulation.FOXA1-activated RGMB-AS1 promoted cell proliferation and invasion in OSA via miR-3614-5p/ANKRD1 pathway." @default.
- W3203619485 created "2021-10-11" @default.
- W3203619485 creator A5034780174 @default.
- W3203619485 creator A5059621249 @default.
- W3203619485 date "2021-09-01" @default.
- W3203619485 modified "2023-09-28" @default.
- W3203619485 title "LncRNA RGMB-AS1 up-regulates ANKRD1 through competitively sponging miR-3614-5p to promote OSA cell proliferation and invasion" @default.
- W3203619485 cites W2162547088 @default.
- W3203619485 cites W2170615237 @default.
- W3203619485 cites W2750107048 @default.
- W3203619485 cites W2775185528 @default.
- W3203619485 cites W2778512171 @default.
- W3203619485 cites W2799489438 @default.
- W3203619485 cites W2909953850 @default.
- W3203619485 cites W2917271874 @default.
- W3203619485 cites W2947200296 @default.
- W3203619485 cites W2949233704 @default.
- W3203619485 cites W2955728049 @default.
- W3203619485 cites W2956007187 @default.
- W3203619485 cites W2957206202 @default.
- W3203619485 cites W2962238782 @default.
- W3203619485 cites W2962733257 @default.
- W3203619485 cites W2963553420 @default.
- W3203619485 cites W2964153589 @default.
- W3203619485 cites W2966064605 @default.
- W3203619485 cites W4211062330 @default.
- W3203619485 cites W4248865982 @default.
- W3203619485 doi "https://doi.org/10.1016/j.arcmed.2021.08.004" @default.
- W3203619485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34583851" @default.
- W3203619485 hasPublicationYear "2021" @default.
- W3203619485 type Work @default.
- W3203619485 sameAs 3203619485 @default.
- W3203619485 citedByCount "0" @default.
- W3203619485 crossrefType "journal-article" @default.
- W3203619485 hasAuthorship W3203619485A5034780174 @default.
- W3203619485 hasAuthorship W3203619485A5059621249 @default.
- W3203619485 hasConcept C104317684 @default.
- W3203619485 hasConcept C119056186 @default.
- W3203619485 hasConcept C127561419 @default.
- W3203619485 hasConcept C137738243 @default.
- W3203619485 hasConcept C1491633281 @default.
- W3203619485 hasConcept C502942594 @default.
- W3203619485 hasConcept C54355233 @default.
- W3203619485 hasConcept C55493867 @default.
- W3203619485 hasConcept C62112901 @default.
- W3203619485 hasConcept C62203573 @default.
- W3203619485 hasConcept C86803240 @default.
- W3203619485 hasConceptScore W3203619485C104317684 @default.
- W3203619485 hasConceptScore W3203619485C119056186 @default.
- W3203619485 hasConceptScore W3203619485C127561419 @default.
- W3203619485 hasConceptScore W3203619485C137738243 @default.
- W3203619485 hasConceptScore W3203619485C1491633281 @default.
- W3203619485 hasConceptScore W3203619485C502942594 @default.
- W3203619485 hasConceptScore W3203619485C54355233 @default.
- W3203619485 hasConceptScore W3203619485C55493867 @default.
- W3203619485 hasConceptScore W3203619485C62112901 @default.
- W3203619485 hasConceptScore W3203619485C62203573 @default.
- W3203619485 hasConceptScore W3203619485C86803240 @default.
- W3203619485 hasLocation W32036194851 @default.
- W3203619485 hasLocation W32036194852 @default.
- W3203619485 hasOpenAccess W3203619485 @default.
- W3203619485 hasPrimaryLocation W32036194851 @default.
- W3203619485 hasRelatedWork W11666936 @default.
- W3203619485 hasRelatedWork W11877123 @default.
- W3203619485 hasRelatedWork W18926617 @default.
- W3203619485 hasRelatedWork W25374763 @default.
- W3203619485 hasRelatedWork W2732079 @default.
- W3203619485 hasRelatedWork W32553455 @default.
- W3203619485 hasRelatedWork W3422088 @default.
- W3203619485 hasRelatedWork W36845310 @default.
- W3203619485 hasRelatedWork W39450543 @default.
- W3203619485 hasRelatedWork W19546173 @default.
- W3203619485 isParatext "false" @default.
- W3203619485 isRetracted "false" @default.
- W3203619485 magId "3203619485" @default.
- W3203619485 workType "article" @default.