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• W3203632626 abstract "<b><i>Background and Purpose:</i></b> The aim of this study was to describe the outcomes of a switch back to anti-vascular endothelial growth factor (VEGF) in diabetic macular oedema (DME) eyes treated temporarily with a dexamethasone implant (DEXi), after an initial poor response to anti-VEGF. <b><i>Methods:</i></b> The study involved a case series. <b><i>Results:</i></b> Twenty-three eyes of 17 patients were included. All were poorly responsive to anti-VEGF and switched to a DEXi after a mean of 12 anti-VEGF injections. The mean best-corrected visual acuity (BCVA) increased from 0.25 ± 0.19 (decimals) to 0.29 ± 0.20 after switching to the DEXi (<i>p</i> = 0.11). BCVA remained stable (0.31 ± 0.23; <i>p</i> = 0.11) after switching back to anti-VEGF, one month after the last injection. The mean central macular thickness (CMT) decreased significantly from 517.0 ± 128.5 μm to 343.4 ± 118.9 μm (<i>p</i> &#x3c; 0.001) after switching to the DEXi. In eyes receiving ≥3 anti-VEGF injections during the switch back, the CMT 1 month after the last anti-VEGF injection was significantly decreased compared to the CMT before the switch to the DEXi (mean change of - 95.55 ± 89.82 μm, <i>p</i> = 0.005). <b><i>Conclusion:</i></b> Switching back poorly responsive DME eyes to anti-VEGF after temporary DEXi therapy is associated with good anatomical and visual outcomes similar to those obtained with the DEXi, provided that at least 3 anti-VEGF injections are administered. The DEXi might restore retinal sensitivity to anti-VEGF." @default.
• W3203632626 created "2021-10-11" @default.
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• W3203632626 date "2021-09-29" @default.
• W3203632626 modified "2023-10-01" @default.
• W3203632626 title "Intravitreal Dexamethasone in Diabetic Macular Oedema: A Way of Enhancing the Response to Anti-VEGF in Non- or Poor Responders?" @default.
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• W3203632626 doi "https://doi.org/10.1159/000519235" @default.
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