FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203663669> ?p ?o ?g. }

• W3203663669 abstract "Coronary artery disease (CAD) is a common cardiovascular disease, and abnormal blood lipid metabolism is an important risk factor. Transforming growth factor-ß (TGF-ß) and its receptor (TGF-ßR) can inhibit the release of inflammatory factors through the SMAD pathway-mediated immune response, thereby suppressing the progression of CAD. Endoglin (TGF-ßRIII), a TGF-ßR family homologous receptor protein, is directly involved in the immunoregulatory process, but the exact mechanism is unclear. This study aimed to clarify the pathophysiological effects of endoglin on the development of atherosclerosis and to explore the mechanism of the signalling pathway.We downloaded the GEO dataset to perform a functional analysis of SMAD family activity and TGF-ß receptor protein expression in the monocyte expression profiles of patients with familial hyperlipidaemia (FH). The effect of endoglin on endothelial cell proliferation, migration, and apoptosis was examined by disrupting the endoglin gene in human umbilical vein endothelial cells (HUVECs) and validated by western blotting. The related genes and pathways regulated by endoglin were obtained by analysing the sequencing data.Research has shown that interference with endoglin can promote the proliferation and migration and significantly inhibit the apoptosis of vascular endothelial cells. Interference with endoglin particularly encourages the expression of VEGFB in vascular endothelial cells.The endoglin gene in vascular endothelial cells regulates the PI3K-Akt, Wnt, TNF, and cellular metabolism pathways by activating the SMAD pathway. RAB26, MR1, CCL2, SLC29A4, IBTK, VEGFB, and GOLGA8B play critical roles. Endoglin interacts closely with 11 proteins such as CCL2 and SEPRINE1, which participate in the vital pathway of plaque formation. Interference with endoglin can alter the course of coronary atherosclerosis." @default.
• W3203663669 created "2021-10-11" @default.
• W3203663669 creator A5000245536 @default.
• W3203663669 creator A5006147109 @default.
• W3203663669 creator A5008171523 @default.
• W3203663669 creator A5008698451 @default.
• W3203663669 creator A5027523425 @default.
• W3203663669 creator A5053200380 @default.
• W3203663669 creator A5060224821 @default.
• W3203663669 creator A5077478846 @default.
• W3203663669 date "2021-10-03" @default.
• W3203663669 modified "2023-09-23" @default.
• W3203663669 title "Negative correlation between endoglin levels and coronary atherosclerosis" @default.
• W3203663669 cites W121993330 @default.
• W3203663669 cites W1832822477 @default.
• W3203663669 cites W1996866382 @default.
• W3203663669 cites W2006738360 @default.
• W3203663669 cites W2010807334 @default.
• W3203663669 cites W2013958991 @default.
• W3203663669 cites W2015336861 @default.
• W3203663669 cites W2043875953 @default.
• W3203663669 cites W2052147002 @default.
• W3203663669 cites W2057366321 @default.
• W3203663669 cites W2105924650 @default.
• W3203663669 cites W2105960693 @default.
• W3203663669 cites W2107277218 @default.
• W3203663669 cites W2111434189 @default.
• W3203663669 cites W2119606908 @default.
• W3203663669 cites W2138146853 @default.
• W3203663669 cites W2153203105 @default.
• W3203663669 cites W2166634853 @default.
• W3203663669 cites W2529749728 @default.
• W3203663669 cites W2579930243 @default.
• W3203663669 cites W2582831851 @default.
• W3203663669 cites W2942286871 @default.
• W3203663669 doi "https://doi.org/10.1186/s12944-021-01545-2" @default.
• W3203663669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8487532" @default.
• W3203663669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34602076" @default.
• W3203663669 hasPublicationYear "2021" @default.
• W3203663669 type Work @default.
• W3203663669 sameAs 3203663669 @default.
• W3203663669 citedByCount "2" @default.
• W3203663669 countsByYear W32036636692022 @default.
• W3203663669 countsByYear W32036636692023 @default.
• W3203663669 crossrefType "journal-article" @default.
• W3203663669 hasAuthorship W3203663669A5000245536 @default.
• W3203663669 hasAuthorship W3203663669A5006147109 @default.
• W3203663669 hasAuthorship W3203663669A5008171523 @default.
• W3203663669 hasAuthorship W3203663669A5008698451 @default.
• W3203663669 hasAuthorship W3203663669A5027523425 @default.
• W3203663669 hasAuthorship W3203663669A5053200380 @default.
• W3203663669 hasAuthorship W3203663669A5060224821 @default.
• W3203663669 hasAuthorship W3203663669A5077478846 @default.
• W3203663669 hasBestOaLocation W32036636691 @default.
• W3203663669 hasConcept C10205521 @default.
• W3203663669 hasConcept C118131993 @default.
• W3203663669 hasConcept C137620995 @default.
• W3203663669 hasConcept C146285616 @default.
• W3203663669 hasConcept C15215337 @default.
• W3203663669 hasConcept C167734588 @default.
• W3203663669 hasConcept C2777025900 @default.
• W3203663669 hasConcept C2781080636 @default.
• W3203663669 hasConcept C28328180 @default.
• W3203663669 hasConcept C502942594 @default.
• W3203663669 hasConcept C6061869 @default.
• W3203663669 hasConcept C62478195 @default.
• W3203663669 hasConcept C86803240 @default.
• W3203663669 hasConcept C95444343 @default.
• W3203663669 hasConceptScore W3203663669C10205521 @default.
• W3203663669 hasConceptScore W3203663669C118131993 @default.
• W3203663669 hasConceptScore W3203663669C137620995 @default.
• W3203663669 hasConceptScore W3203663669C146285616 @default.
• W3203663669 hasConceptScore W3203663669C15215337 @default.
• W3203663669 hasConceptScore W3203663669C167734588 @default.
• W3203663669 hasConceptScore W3203663669C2777025900 @default.
• W3203663669 hasConceptScore W3203663669C2781080636 @default.
• W3203663669 hasConceptScore W3203663669C28328180 @default.
• W3203663669 hasConceptScore W3203663669C502942594 @default.
• W3203663669 hasConceptScore W3203663669C6061869 @default.
• W3203663669 hasConceptScore W3203663669C62478195 @default.
• W3203663669 hasConceptScore W3203663669C86803240 @default.
• W3203663669 hasConceptScore W3203663669C95444343 @default.
• W3203663669 hasFunder F4320321001 @default.
• W3203663669 hasIssue "1" @default.
• W3203663669 hasLocation W32036636691 @default.
• W3203663669 hasLocation W32036636692 @default.
• W3203663669 hasLocation W32036636693 @default.
• W3203663669 hasLocation W32036636694 @default.
• W3203663669 hasOpenAccess W3203663669 @default.
• W3203663669 hasPrimaryLocation W32036636691 @default.
• W3203663669 hasRelatedWork W1520156967 @default.
• W3203663669 hasRelatedWork W2027244603 @default.
• W3203663669 hasRelatedWork W2060548346 @default.
• W3203663669 hasRelatedWork W2061448543 @default.
• W3203663669 hasRelatedWork W2096384326 @default.
• W3203663669 hasRelatedWork W2128005193 @default.
• W3203663669 hasRelatedWork W2348638175 @default.
• W3203663669 hasRelatedWork W2374945538 @default.
• W3203663669 hasRelatedWork W2885230476 @default.
• W3203663669 hasRelatedWork W3029355997 @default.

• next