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- W3203669856 abstract "Ethanol (Direct) extracts of mangrove plants, namely, Avicennia officinalis Linn. and Rhizophora mucronata Lam. were included for the present in vitro study. Pepsin was used as a substitute for HIV-protease to evaluate inhibitory activity of these extracts, as pepsin has close resemblance with HIV-protease in proteolytic activity. R. mucronata revealed potent inhibitory activity than A. officinalis with IC50 value of 14.63 µg/mL. In our earlier study, R. mucronata exerted anti-HIV activity via multiple mechanisms of action; viz., interference with the gp120 / CD4 interaction and inhibition of HIV-reverse transcriptase. In the present study, it also showed potent inhibitory activity against pepsin enzyme (indirectly against HIV-protease) which may be due its high flavonoids content." @default.
- W3203669856 created "2021-10-11" @default.
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- W3203669856 date "2013-07-28" @default.
- W3203669856 modified "2023-09-28" @default.
- W3203669856 title "EVALUATION OF MANGROVE PLANTS AS PUTATIVE HIV-PROTEASE INHIBITORS" @default.
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- W3203669856 doi "https://doi.org/10.53879/id.50.07.p0041" @default.
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