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- W3203704744 abstract "The use of polydiacetylene (PDA) vesicles in sensing systems are wide-spread due to the interesting optical properties of this stimuli-responsive material; however, agglutination based sensing with PDA have been relatively underutilized. To demonstrate the means for rapidly generating an agglutination probe based on peptide-displaying polydiacetylene vesicles, we implement here the use of a biotin mimetic peptide functionalized to a diacetylene amphiphile for proof-of-concept detection of a multivalent target, specifically streptavidin. Tuning of the vesicle composition revealed a distinct limit in the surface density of peptide amphiphile that could be displayed for this particular peptide sequence. A wide operational detection range was demonstrated, and the result also revealed an effective agglutination response of the PDA-based probe to streptavidin suggesting possible use of future formulations in profiling other multivalent targets." @default.
- W3203704744 created "2021-10-11" @default.
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- W3203704744 date "2021-09-01" @default.
- W3203704744 modified "2023-09-26" @default.
- W3203704744 title "Self-Assembled Peptide-Labeled Probes for Agglutination-Based Sensing" @default.
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- W3203704744 doi "https://doi.org/10.1007/s13233-021-9079-3" @default.
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